FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Det2180
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General Information
Symbol
Dmel\Det2180
Species
D. melanogaster
Name
FlyBase ID
FBal0301287
Feature type
allele
Associated gene
Dmel\Det
Associated Insertion(s)
PBac{RB}Det2180
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{RB}Det2180
    Cytology
    Description

    PBac{RB}Det2180 is inserted in the 5' regulatory region of Det.

    (Mathieu et al., 2013)
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{RB}
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Approximately 20% of Det2180; DetS125A.T:Avic\GFP mutant females display egg chambers with only eight cells.

        Approximately 20% of Det2180; DetS125A.T129A.T:Avic\GFP mutant females display egg chambers with only eight cells.

        (Mathieu et al., 2013)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Det2180 is rescued by DetGFP

        (Mathieu et al., 2013)
        Partially rescued by

        Det2180 is partially rescued by DetS125A.GFP

        (Mathieu et al., 2013)
        Not rescued by

        Det2180 is not rescued by DetC97A.GFP

        (Mathieu et al., 2013)

        Det2180 is not rescued by DetΔBIR.GFP

        (Mathieu et al., 2013)
        Partially rescues

        Scer\GAL4VP16.nanos.UTR/Det2180 partially rescues DetS125E.UASp.GFP

        (Mathieu et al., 2013)
        Comments

        The presence of Det+t.T:Avic\GFP rescues viability and diploidy in Det2180.

        A Det2180/+ background partially rescues the extra germline cells phenotype found in females expressing DetS125E.Scer\UAS.P\T.T:Avic\GFP under the control of Scer\GAL4nos.UTR.T:Hsim\VP16.

        The presence of DetT129A.T:Avic\GFP rescues viability and diploidy in Det2180. However, the number of germline cells per egg chamber is not rescued.

        The presence of DetS125A.T:Avic\GFP rescues viability and diploidy in Det2180. However, the number of germline cells per egg chamber is not rescued.

        The presence of DetS125A.T129A.T:Avic\GFP rescues viability and diploidy in Det2180. However, the number of germline cells per egg chamber is not rescued.

        (Mathieu et al., 2013)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        Det2180
        svn2180
        (Thomas et al., 2021)
        Name Synonyms
        Secondary FlyBase IDs
          References (2)