FlyBase Allele Report: Dmel\mir-2b-1[KO]

General Information

Symbol

Dmel\mir-2b-1^KO

Species

D. melanogaster

Name

FlyBase ID

FBal0301916

Feature type

allele

Associated gene

Dmel\mir-2b-1

Associated Insertion(s)

TI{TI}mir-2b-1^KO

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Chen et al., 2014)

Mutagen

ends-out gene targeting

(Chen et al., 2014)

FLPase

(Chen et al., 2014)

I-SceI

(Chen et al., 2014)

Progenitor genotype

Associated Insertion(s)

TI{TI}mir-2b-1^KO

Cytology

Description

The mir-2b-1 hairpin has been deleted and replaced by a loxP cassette containing the w^+mW.hs marker. It is not known whether or not expression of the host Btk29A gene is affected.

(Chen et al., 2014)

Allele components

Component

Use(s)

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased rate of larval locomotory behavior

(Menzies et al., 2024)

decreased rate of movement | embryonic stage

(Menzies et al., 2024)

female fertile

(Chen et al., 2014)

male fertile

(Chen et al., 2014)

viable

(Chen et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

mir-2b-1^KO has decreased rate of larval locomotory behavior phenotype, suppressible by Scer\GAL4^iav.PK/Motor^KK111674

(Menzies et al., 2024)

mir-2b-1^KO has decreased rate of movement | embryonic stage phenotype, suppressible by Scer\GAL4^elav.PU/Motor^KK111674

(Menzies et al., 2024)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

mir-2b-1^KO is rescued by mir-2b-1^UAS.pLUC/Scer\GAL4^elav.PU

(Menzies et al., 2024)

mir-2b-1^KO is rescued by mir-2b-1^UAS.pLUC/Scer\GAL4^iav.PK

(Menzies et al., 2024)

Not rescued by

mir-2b-1^KO is not rescued by mir-2b-1^UAS.pLUC/Scer\GAL4^VGlut1-OK371

(Menzies et al., 2024)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

58915

w^*; TI{TI}mir-2b-1^KO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

mir-2b-1^KO

(Niu et al., 2019)

ΔmiR-2b-1

(Menzies et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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