FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dop1R2UAS.cHa
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General Information
Symbol
Dmel\Dop1R2UAS.cHa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Han
FlyBase ID
FBal0302101
Feature type
allele
Associated gene
Dmel\Dop1R2
Associated Insertion(s)
Carried in Construct
P{UAS-DAMB.H}
Key Links
Transgenic product class
wild_type
(Cassar et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Cassar et al., 2015)
Mutagen
in vitro construct
(Cassar et al., 2015)
Progenitor genotype
Carried in construct
P{UAS-DAMB.H}
Cytology
Description

UAS regulatory sequences drive expression of Dop1R2.

(Cassar et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Dop1R2
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 1 )
       

      Dop1R2Scer\UAS.cHa exacerbates the phenotypes seen in a paraquat-induced model of Parkinson's Disease.

      (Cassar et al., 2015)
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Dop1R2Scer\UAS.cHa under the control of Scer\GAL4ple.PF results in decreased resistance of flies to paraquat intoxication. Increased survival rates are seen at 24 hours after ingestion and 2 hours after direct application to the ventral nerve cord (VNC) of decapitated flies.

      Expression of Dop1R2Scer\UAS.cHa in glutamatergic neurons under the control of Scer\GAL4VGlut.PC decreases survival rates of decapitated flies following direct application of dopamine to the ventral nerve cord (VNC).

      Expression of Dop1R2Scer\UAS.cHa in glutamatergic neurons under the control of Scer\GAL4VGlut.PC, serotonergic neurons (Scer\GAL4Trh.PB), or in glial cells (Scer\GAL4repo) has no effect on viability in the absence of paraquat. Expression in all neurons (Scer\GAL4elav-C155), dopaminergic neurons (Scer\GAL4ple.PF) or cholinergic neurons (Scer\GAL4Cha.7.4) results in lethality at the pupal stage.

      (Cassar et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dop1R2Scer\UAS.cHa
      Dop1R2UAS.cHa
      Name Synonyms
      Saccharomyces cerevisiae UAS construct a of Han
      Secondary FlyBase IDs
        References (1)