FlyBase Allele Report: Amel\MRJP1[UAS.cKa]

General Information

Symbol

Amel\MRJP1^UAS.cKa

Species

A. mellifera

Name

Saccharomyces cerevisiae UAS construct a of Kamakura

FlyBase ID

FBal0302213

Feature type

allele

Associated gene

Amel\MRJP1

Associated Insertion(s)

Carried in Construct

P{UAS-royalactin}

Transgenic product class

wild_type

(Kamakura, 2011)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Kamakura, 2011)

Mutagen

in vitro construct

(Kamakura, 2011)

Progenitor genotype

Carried in construct

P{UAS-royalactin}

Cytology

Description

UAS regulatory sequences drive expression of Amel\MRJP1.

(Kamakura, 2011)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Amel\MRJP1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal developmental rate, with Scer\GAL4^Act.PU

(Kamakura, 2011)

abnormal developmental rate, with Scer\GAL4^ppl.PP

(Kamakura, 2011)

abnormal developmental rate, with Scer\GAL4^rho.PU

(Kamakura, 2011)

increased body size, with Scer\GAL4^Act.PU

(Kamakura, 2011)

increased body size, with Scer\GAL4^ppl.PP

(Kamakura, 2011)

increased body size, with Scer\GAL4^rho.PU

(Kamakura, 2011)

increased cell size, with Scer\GAL4^Act.PU

(Kamakura, 2011)

increased fecundity, with Scer\GAL4^Act.PU

(Kamakura, 2011)

increased fecundity, with Scer\GAL4^ppl.PP

(Kamakura, 2011)

increased fecundity, with Scer\GAL4^rho.PU

(Kamakura, 2011)

long lived, with Scer\GAL4^Act.PU

(Kamakura, 2011)

long lived | female limited, with Scer\GAL4^ppl.PP

(Kamakura, 2011)

long lived | female limited, with Scer\GAL4^rho.PU

(Kamakura, 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

Transgenic flies expressing Scer\GAL4^Act.PU>Amel\MRJP1^Scer\UAS.cKa show increased body size, cell size, fecundity, longevity, and shortened developmental time compared with controls.

Overexpression of Amel\MRJP1^Scer\UAS.cKa specifically in the fat body using Scer\GAL4^ppl.PP induces increased body size, fecundity and longevity compared with controls.

Overexpression of Amel\MRJP1^Scer\UAS.cKa using Scer\GAL4^rho.PU induces increased body size, fecundity and longevity compared with controls.

When Amel\MRJP1^Scer\UAS.cKa is overexpressed using Scer\GAL4^P0206 or Scer\GAL4^Aug21, it does not alter body size or developmental time of the transgenic animals compared to controls.

(Kamakura, 2011)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Amel\MRJP1^UAS.cKa, Scer\GAL4^rho.PU has increased body size phenotype, suppressible by Egfr^RNAi.UAS.cUa, Scer\GAL4^rho.PU

(Kamakura, 2011)

Amel\MRJP1^UAS.cKa, Scer\GAL4^rho.PU has increased body size phenotype, suppressible by S6k^KQ.UAS, Scer\GAL4^rho.PU