FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Scer\GAL4NP2721
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General Information
Symbol
Scer\GAL4NP2721
Species
S. cerevisiae
Name
FlyBase ID
FBal0302626
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
P{GawB}NP2721
Carried in Construct
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    P{GawB}NP2721
    Cytology
    Description
    Allele components
    Component
    Use(s)
    Inserted element
    P{GawB}
    Encoded product / tool
    GAL4
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Activation of Scer\GAL4NP2721-expressing dorsal paired medial (DPM) neurons results in an immediate and dramatic increase in sleep. Activating DPMs does not alter the level of locomotor activity during waking periods. The flies are immediately arousable by gentle tapping and have normal geotaxis and locomotion. Upon cessation of activation, flies show reduced sleep. Blocking vesicle release in these flies completely blocks these increases in sleep.

        Silencing Scer\GAL4NP2721-expressing dorsal paired medial (DPM) neurons results in a small but significant decrease in levels of nighttime sleep relative to controls.

        (Haynes et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        Scer\GAL4NP2721
        Name Synonyms
        Secondary FlyBase IDs
          References (2)