Open Close
Reference
Citation
Haynes, P.R., Christmann, B.L., Griffith, L.C. (2015). A single pair of neurons links sleep to memory consolidation in Drosophila melanogaster.  eLife 4(): e03868.
FlyBase ID
FBrf0227396
Publication Type
Research paper
Abstract

Sleep promotes memory consolidation in humans and many other species, but the physiological and anatomical relationships between sleep and memory remain unclear. Here, we show the dorsal paired medial (DPM) neurons, which are required for memory consolidation in Drosophila, are sleep-promoting inhibitory neurons. DPMs increase sleep via release of GABA onto wake-promoting mushroom body (MB) α'/β' neurons. Functional imaging demonstrates that DPM activation evokes robust increases in chloride in MB neurons, but is unable to cause detectable increases in calcium or cAMP. Downregulation of α'/β' GABAA and GABABR3 receptors results in sleep loss, suggesting these receptors are the sleep-relevant targets of DPM-mediated inhibition. Regulation of sleep by neurons necessary for consolidation suggests that these brain processes may be functionally interrelated via their shared anatomy. These findings have important implications for the mechanistic relationship between sleep and memory consolidation, arguing for a significant role of inhibitory neurotransmission in regulating these processes.

PubMed ID
PubMed Central ID
PMC4305081 (PMC) (EuropePMC)
Related Publication(s)
Personal communication to FlyBase

Superclomeleon constructs and insertions.
Haynes and Griffith, 2015.4.3, Superclomeleon constructs and insertions. [FBrf0228231]

Associated Information
Comments
Associated Files
Other Information
Secondary IDs
    Language of Publication
    English
    Additional Languages of Abstract
    Parent Publication
    Publication Type
    Journal
    Abbreviation
    eLife
    Title
    eLife
    ISBN/ISSN
    2050-084X
    Data From Reference