FlyBase Allele Report: Dmel\sgg[DN.UAS.cUa]

General Information

Symbol

Dmel\sgg^DN.UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0302753

Feature type

allele

Associated gene

Dmel\sgg

Associated Insertion(s)

Carried in Construct

P{UAS-sgg.DN.U}

Key Links

Transgenic product class

dominant_negative_variant

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

dominant_negative_variant

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-sgg.DN.U}

Cytology

Description

UAS regulatory sequences drive expression of a dominant negative form of sgg.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

sgg

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Hsap\TAF15^UAS.cCa

(Choi et al., 2021)

exacerbates tauopathy

modeled by Hsap\MAPT^UAS.cAa

(Cowan et al., 2015)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of sgg^{DN.Scer\UAS.cUa} in eye disc clones under the control of a GAL4 driver does not significantly increase apoptosis levels compared to controls.

(Zhang et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

sgg^DN.UAS.cUa, Scer\GAL4^unspecified is an enhancer of increased cell death | somatic clone phenotype of Rbf^HMS03004, Scer\GAL4^unspecified

(Zhang et al., 2014)

Suppressor of

Statement

Reference

sgg^DN.UAS.cUa/Scer\GAL4^VGlut1-OK371 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of iav^hypoB-1

(Wong et al., 2014)

Phenotype Manifest In

Enhancer of

Statement

Reference

sgg^DN.UAS.cUa, Scer\GAL4^unspecified is an enhancer of eye disc | somatic clone phenotype of Rbf^HMS03004, Scer\GAL4^unspecified

(Zhang et al., 2014)

Suppressor of

Statement

Reference

sgg^DN.UAS.cUa/Scer\GAL4^VGlut1-OK371 is a suppressor of NMJ bouton | third instar larval stage | decreased number phenotype of iav^hypoB-1

(Wong et al., 2014)

sgg^DN.UAS.cUa/Scer\GAL4^VGlut1-OK371 is a suppressor of embryonic/larval hypodermal muscle cell | third instar larval stage phenotype of iav^hypoB-1

(Wong et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

sgg^{DN.Scer\UAS.cUa}

sgg^DN.UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (5)

Report Sections

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