FlyBase Allele Report: Hsap\PRDX3[UAS.cAa]

General Information

Symbol

Hsap\PRDX3^UAS.cAa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Angeles

FlyBase ID

FBal0303917

Feature type

allele

Associated gene

Hsap\PRDX3

Associated Insertion(s)

Carried in Construct

P{UAS-PRDX3.A}

Key Links

Transgenic product class

wild_type

(Angeles et al., 2014)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Angeles et al., 2014)

Mutagen

in vitro construct

(Angeles et al., 2014)

Progenitor genotype

Carried in construct

P{UAS-PRDX3.A}

Cytology

Description

UASt regulatory sequences drive expression of Hsap\PRDX3.

(Angeles et al., 2014)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\PRDX3

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsap\LRRK2^{G2019S.UAS.Tag:MYC}

(Angeles et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Hsap\PRDX3^UAS.cAa, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Hsap\LRRK2^{WT.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^elav.PU has short lived phenotype, suppressible | partially by Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Angeles et al., 2014)

Suppressor of

Statement

Reference

Hsap\PRDX3^UAS.cAa, Scer\GAL4^elav.PU is a suppressor | partially of short lived phenotype of Hsap\LRRK2^{WT.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^Ddc.PU is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PU

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^elav.PU is a suppressor | partially of short lived phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^elav.PU

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^Ddc.PU is a suppressor of abnormal neuroanatomy | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PU

(Angeles et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\PRDX3^UAS.cAa, Scer\GAL4^Ddc.PU is a suppressor of dopaminergic PPM1 neuron | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PU

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^Ddc.PU is a suppressor of dopaminergic PPM3 neuron | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PU

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^Ddc.PU is a suppressor of dopaminergic PPL1 neuron | progressive phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^Ddc.PU

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^how-24B is a suppressor of myofibril phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^how-24B

(Angeles et al., 2014)

Hsap\PRDX3^UAS.cAa, Scer\GAL4^how-24B is a suppressor of mitochondrion phenotype of Hsap\LRRK2^{G2019S.UAS.Tag:MYC}, Scer\GAL4^how-24B

(Angeles et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of Hsap\LRRK2^{WT.Scer\UAS.T:Hsap\MYC} partially suppresses the decreased lifespan induced by the expression of Hsap\PRDX3^Scer\UAS.cAa under the control of Scer\GAL4^elav.PU.

(Angeles et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\PRDX3^Scer\UAS.cAa

Hsap\PRDX3^UAS.cAa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Angeles

Secondary FlyBase IDs

References (1)

Report Sections

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