FlyBase Allele Report: Dmel\Su(var)3-7[7.1A]

General Information

Symbol

Dmel\Su(var)3-7^7.1A

Species

D. melanogaster

Name

FlyBase ID

FBal0304388

Feature type

allele

Associated gene

Dmel\Su(var)3-7

Associated Insertion(s)

TI{TI}Su(var)3-7^7.1A

Carried in Construct

Key Links

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

ends-in gene targeting

(Seum et al., 2002)

FLPase

(Seum et al., 2002)

I-SceI

(Seum et al., 2002)

Progenitor genotype

Associated Insertion(s)

TI{TI}Su(var)3-7^7.1A

Cytology

Description

Three copies of Su(var)3-7 are present, with a copy of the y⁺²⁰⁸³ marker being present between the 5' and middle copy and also between the middle and 3' copy. The 5' copy contains a stop codon at position 2240. It is fused at its C-terminus in frame with 157 amino acids of the y protein (this structure is due to the cloning procedure used to make the donor construct). The middle copy contains a stop codon at position 830. Again, it is fused at its C-terminus in frame with 157 amino acids of the y protein. The 3' copy contains a stop codon at position 2240.

(Seum et al., 2002)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during third instar larval stage | maternal effect

(Seum et al., 2002)

suppressor of variegation, with In(1)w^m4h

(Seum et al., 2002)

suppressor of variegation, with In(2)Heidi-P{Winkelried}D

(Seum et al., 2002)

suppressor of variegation, with In(2R)bw^VDe2

(Seum et al., 2002)

viable

(Seum et al., 2002)

Phenotype Manifest In

polytene chromosome | male

(Spierer et al., 2005)

Detailed Description

Statement

Reference

The X chromosome is shorter than normal and bloated in polytene chromosome squashes from male homozygous Su(var)3-7^7.1A third instar larvae.

The X chromosome is shorter than normal and bloated in polytene chromosome squashes from male homozygous Dp(3;3)Su(var)3-7^7.1A third instar larvae.

(Spierer et al., 2005)

Loss of maternal and zygotic Su(var)3-7 is lethal. .

Loss of maternal and zygotic Su(var)3-7 is lethal.

(Seum et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

P{P-Sal}Pak3^P-Sal, P{lacW}Dplac, Su(var)3-7^7.1A has suppressor of variegation phenotype

(Bushey and Locke, 2004)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

When P{P-Sal}Pak3^P-Sal is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w[-] background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Su(var)3-7^7.1A.

When P{P-Sal}89D is present, the w gene of the P{lacW}ci^Dplac insertion variegates, resulting (in a w^- background) in an eye that is mostly white with a few patches of red ommatidia. This P-element-dependent silencing of P{lacW}ci^Dplac is dominantly suppressed by Dp(3;3)Su(var)3-7^7.1A.

(Bushey and Locke, 2004)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Dp(3;3)Su(var)3-7^7.1A

Su(var)3-7^7.1A.3'

Su(var)3-7^7.1A.5'

Su(var)3-7^7.1A.mid

Su(var)3-7^7.1A

(Spierer et al., 2005, Bushey and Locke, 2004, Seum et al., 2002)

Name Synonyms

Secondary FlyBase IDs

FBal0147396
FBal0147394
FBal0147395
FBab0037618

References (3)

Report Sections

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