FlyBase Allele Report: Dmel\Dh31[51]

General Information

Symbol

Dmel\Dh31⁵¹

Species

D. melanogaster

Name

FlyBase ID

FBal0304655

Feature type

allele

Associated gene

Dmel\Dh31

Associated Insertion(s)

Carried in Construct

Also Known As

Dh31^#51

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Head et al., 2015)

Progenitor genotype

Cytology

Description

The allele was generated by imprecise excision of a P-element. It contains a deletion of the entire active peptide encoded by Dh31.

(Head et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:8,492,689..8,493,423 [-]

Comment:

735 bp deletion resulting from the imprecise excision of the progenitor insertion. 8 bp are inserted at the site of the deletion. The deletion boundaries were taken from the reported genomic sequence.

(Head et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal sleep | adult stage

(Goda et al., 2016)

abnormal temperature response | adult stage

(Goda et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Dh31⁵¹ mutants show a normal temperature preference during daytime, as compare to controls.

(Goda et al., 2018)

Dh31⁵¹ homozygous adults, reared under 12:12 light:dark zeitgeber cycle, present increased levels of sleep between zeitgeber times 21 and 24, but do not present significantly altered locomotor activity rhythms in either alternating light-dark cycles or constant dark conditions, as compared to controls.

Dh31⁵¹ homozygous adults, reared under 12:12 light:dark zeitgeber cycle, present a significantly lower night-onset preferred temperature decrease (between zeitgeber times 10-12 and 13-15), but a similar day-time preferred temperature increase (between zeitgeber times 1-3h and 10-12), as compared to controls.

(Goda et al., 2016)

Dh31⁵¹ mutants exhibit light-dependent temperature preference similar to that of wild-type.

(Head et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, suppressible | partially by Scer\GAL4^tim.UAS/Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2018)

NOT suppressed by

Statement

Reference

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Scer\GAL4^GMR18H11/Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^Clk.int1-3/Scer\GAL80^Pdf.PS

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Scer\GAL4^NP6301/Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^tim.UAS

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^P2.4.Pdf

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^GMR18H11

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^Clk.int1-3/Scer\GAL80^Pdf.PS

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Scer\GAL4^NP6301/Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2018)

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^P2.4.Pdf

(Goda et al., 2018)

Dh31⁵¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^Clk.int1-3/Scer\GAL80^Pdf.PS

(Goda et al., 2016)

Dh31⁵¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Scer\GAL4^Pdf.PU/Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2016)

Dh31⁵¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Scer\GAL4^Clk.1.5/Pdf^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2016)

Dh31⁵¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Scer\GAL4^Clk.1.5/Pdf^{UAS.SCR.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2016)

Dh31⁵¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Pdf^{UAS.SCR.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^Clk.int1-3/Scer\GAL80^Pdf.PS

(Goda et al., 2016)

Dh31⁵¹ has abnormal temperature response | adult stage phenotype, non-suppressible by Scer\GAL4^Pdf.PU/Pdf^{UAS.SCR.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2016)

Other

Statement

Reference

Dh31⁵¹, Pdf⁰¹ has abnormal temperature response | adult stage phenotype

(Goda et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Dh31⁵¹, Pdf⁰¹ double mutants show a relatively high and constant temperature preference (~26[o]C) during daytime in 12h:12h light:dark cycles, and show a relatively low and constant temperature (~24[o]C) under constant darkness conditions, as compared o controls.

(Goda et al., 2018)

Expression of either Pdf^{Scer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1} or Pdf^{Scer\UAS.SCR.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1}, under either the combined control of Scer\GAL4^Clk.int1-3 and Scer\GAL80^Pdf.PS, or the control of either Scer\GAL4^Pdf.PU, Scer\GAL4^Clk.4.1M or Scer\GAL4^Clk.4.5F, does not rescue the lower night-onset preferred temperature decrease observed in Dh31⁵¹ homozygous mutant adults.

(Goda et al., 2016)

Dh31⁵¹; Pdf⁰¹ double mutants exhibit light-dependent temperature preference similar to that of wild-type.

(Head et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Dh31⁵¹ is rescued by Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}/Scer\GAL4^Clk.int1-3/Scer\GAL80^Pdf.PS

(Goda et al., 2016)

Not rescued by

Dh31⁵¹ is not rescued by Scer\GAL4^Pdf.PU/Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2016)

Dh31⁵¹ is not rescued by Scer\GAL4^Clk.1.5/Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

(Goda et al., 2016)

Comments

Expression of Dh31^{Scer\UAS.ML.T:SS-trypsin.T:Hsap\MYC.T:GPI-lynx1} under the combined control of Scer\GAL4^Clk.int1-3 and Scer\GAL80^Pdf.PS, but not when under the control of either Scer\GAL4^Pdf.PU or Scer\GAL4^Clk.4.5F, rescues the lower night-onset preferred temperature decrease observed in Dh31⁵¹ homozygous mutant adults.

(Goda et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Dh31^#51

(Kurogi et al., 2023, Lyu et al., 2023, Goda et al., 2019, Goda et al., 2018, Goda et al., 2016, Head et al., 2015)

Dh31⁵¹

(Ma et al., 2020)

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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