FlyBase Gene Report: Dmel\Dh31

General Information

Symbol

Dmel\Dh31

Species

D. melanogaster

Name

Diuretic hormone 31

Annotation Symbol

CG13094

Feature Type

protein_coding_gene

FlyBase ID

FBgn0032048

Gene Model Status

Current

Stock Availability

93 publicly available

Gene Summary

Diuretic hormone 31 (Dh31) encodes a neuropeptide which regulates fluid secretion and controls the switch between feeding and courtship behaviour. Dh31 levels increase following the consumption of protein-rich food. In the brain Dh31 excites two distinct populations of neurons, responsible for two parallel pathways, one inhibiting feeding through AstC and the other promoting courtship through Crz. [Date last reviewed: 2022-03-10] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Drm-DH₃₁, diuretic hormone

Key Links

Genomic Location

Cytogenetic map

29D1-29D3

Sequence location

2L:8,491,868..8,506,845 [-]

Recombination map

2-33

RefSeq locus

NT_033779 REGION:8491868..8506845

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

enables diuretic hormone activity

inferred from direct assay

(Coast et al., 2001)

enables G protein-coupled receptor binding

inferred from physical interaction with FLYBASE:Dh31-R; FB:FBgn0052843

(Johnson et al., 2005)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables diuretic hormone activity

inferred from electronic annotation with InterPro:IPR034439

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN002221967

(GO Reference Genome Project, 2011-)

enables G protein-coupled receptor binding

inferred from biological aspect of ancestor with PANTHER:PTN002221967

(GO Reference Genome Project, 2011-)

Biological Process (7 terms)

Terms Based on Experimental Evidence (7 terms)

CV Term

Evidence

References

involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway

inferred from direct assay

(Choi et al., 2009)

involved_in body fluid secretion

inferred from direct assay

(Coast et al., 2001)

acts_upstream_of_positive_effect courtship behavior

inferred from mutant phenotype

(Lin et al., 2022)

involved_in G protein-coupled receptor signaling pathway

inferred from direct assay

(Johnson et al., 2005)

involved_in negative regulation of feeding behavior

inferred from mutant phenotype

(Lin et al., 2022)

involved_in positive regulation of circadian sleep/wake cycle, wakefulness

inferred from mutant phenotype

(Kunst et al., 2014)

involved_in response to temperature stimulus

inferred from mutant phenotype

(Goda et al., 2018)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in body fluid secretion

inferred from electronic annotation with InterPro:IPR034439

(InterPro Project Members, 2004-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Goda et al., 2018)

located_in extracellular space

inferred from direct assay

(Reiher et al., 2011)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in extracellular space

inferred from biological aspect of ancestor with PANTHER:PTN002221967

(GO Reference Genome Project, 2011-)

located_in extracellular space

inferred from sequence model

(FlyBase Curators, 2011-)

Gene Group (FlyBase)

NEUROPEPTIDES

Protein Family (UniProt)

Belongs to the diuretic hormone class 2 family. (Q9VLK4)

Protein Signatures (InterPro)

Diuretic hormone class 2-like

Summaries

Gene Snapshot

Gene Group (FlyBase)

NEUROPEPTIDES -: Neuropeptides are secreted into the extracellular space where they interact with cell surface receptors (usually G protein coupled receptors). They are extremely diverse, acting as neurotransmitters, neuromodulators, hormones or growth factors. (Adapted from FBrf0211443 and PMID:27813667).

Protein Function (UniProtKB)

Regulation of fluid secretion. Stimulates Malpighian tubules fluid secretion by activating the apical membrane V-ATPase via cyclic AMP of principal cells in the main secretory segment.

(UniProt, Q9VLK4)

Summary (Interactive Fly)

regulation of sleep - regulates a preferred temperature decrease at night-onset - midgut cells that express Dh31 and tachykinin are activated by the presence of proteins and amino acids - increases the contraction frequency in the anterior midgut

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dh31 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VLK4)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.52

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dh31-RA

FBtr0079699

NM_078790

1292

116

Dh31-RC

FBtr0079700

NM_164825

1295

117

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dh31-PA

FBpp0079307

12.6

116

8.05

FBpp0079308

12.9

117

8.48

Q8IPF3

NP_723401

AAN10672

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Diuretic hormone class 2-like

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dh31 using the Feature Mapper tool.

External Data

Crossreferences

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.68

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16 -- 17

VUM5 interneuron of embryonic abdominal segment 5

(Fontana and Crews, 2012)

RNA-seq

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 16

ventral midline of embryo

(Fontana and Crews, 2012)

Additional Descriptive Data

Dh31 is expressed in the embryo in the midline in VUM interneuron 2 (called iVUM5 in the paper) of segment A7 and in one cell each in the mandibular and maxillary segments.

(Fontana and Crews, 2012)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval anterior midgut

(Veenstra, 2009)

embryonic/larval middle midgut | restricted

(Veenstra, 2009)

embryonic/larval copper cell

(Veenstra, 2009)

embryonic/larval midgut large flat cell

(Veenstra, 2009)

larval midgut neutral region

(Veenstra, 2009)

larval midgut transition region

(Veenstra, 2009)

larval midgut alkaline region

(Veenstra, 2009)

adult stage

adult midgut

Comment: caudal half of posterior midgut

(Veenstra et al., 2008)

ellipsoid body inner posterior domain

(Kunst et al., 2014)

DN1 neuron | subset

(Kunst et al., 2014)

adult posterior midgut | posterior | restricted

(Park et al., 2016)

adult enteroendocrine cell | subset

(Park et al., 2016)

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

embryonic/larval midgut

Comment: peptides

(Reiher et al., 2011)

Additional Descriptive Data

Dh31 protein co-localises with per and Pdfr in five DN1-neurons.

(Kunst et al., 2014)

Dh31 peptides were detected in extracts from adult and larval midguts.

(Reiher et al., 2011)

Dh31 protein is expressed throughout the midgut and are particularly abundant in the anterior midgut and the anterior middle midgut junction but are also present in the middle and posterior midgut. The immunoreactivity is reduced once the larva reaches the wandering stage.

(Veenstra, 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in cytoplasm

inferred from direct assay

(Goda et al., 2018)

located_in extracellular space

inferred from direct assay

(Reiher et al., 2011)

Expression Deduced from Reporters

Reporter: P{GMR20A02-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

Reporter: P{GMR20D02-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult pars intercerebralis | restricted

(Kunst et al., 2014)

adult gnathal ganglion | restricted

(Kunst et al., 2014)

adult antennal lobe | restricted

(Kunst et al., 2014)

ventrolateral protocerebrum | restricted

(Kunst et al., 2014)

Reporter: P{GMR21C09-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult gnathal ganglion | restricted

(Kunst et al., 2014)

adult antennal lobe | restricted

(Kunst et al., 2014)

adult mushroom body | restricted

(Kunst et al., 2014)

medulla | restricted

(Kunst et al., 2014)

adult pars intercerebralis | restricted

(Kunst et al., 2014)

Reporter: P{GMR21E02-GAL4}

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

larval A27e neuron

(Schneider-Mizell et al., 2016)

adult stage

adult gnathal ganglion | restricted

(Kunst et al., 2014)

medulla | restricted

(Kunst et al., 2014)

lobula | restricted

(Kunst et al., 2014)

fan-shaped body | restricted

(Kunst et al., 2014)

anterior superior medial protocerebrum | restricted

(Kunst et al., 2014)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dh31 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dh31

View exonic expression by tissue for Dmel\Dh31

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032048

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34181/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032048

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032048

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032048

Flygut - An atlas of the Drosophila adult midgut

FBgn0032048

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 13 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 10 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dh31

Transgenic constructs containing regulatory region of Dh31

Aberrations (Deficiencies and Duplications) ( 2 )

Inferred from experimentation ( 2 )

Gene disrupted in

Df(2L)Exel7038

(Ryder, 2004.4.26)

Gene partially disrupted in

Df(2L)CRIMIC-CR70882

(Gene Disruption Project members, 2018-)

Inferred from location ( 7 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Dh31^KG09001

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dh31^GD4601

viable, with Scer\GAL4^Mef2.PR

Dh31^GD4601

viable, with Scer\GAL4^pnr-MD237

Dh31^GD4601

Sterility

Allele

fertile

Dh31^KG09001

Other Phenotypes

Allele

abnormal circadian rhythm, with Scer\GAL4^nSyb.PU

Dh31^{UAS.ML.Tag:SS(trypsin).Tag:MYC.Tag:GPI(lynx1)}

abnormal sleep

Dh31^KG09001

abnormal sleep, with Scer\GAL4^GMR20A02

Dh31^UAS.cKa

abnormal sleep, with Scer\GAL4^GMR43D05

Dh31^UAS.cKa

abnormal sleep, with Scer\GAL4^nSyb.PU

abnormal sleep (with Df(2L)Exel7038)

Dh31^KG09001

abnormal sleep | adult stage

Dh31⁵¹

abnormal temperature response | adult stage

Dh31⁵¹

Phenotype manifest in

Allele

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (0)

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (0)

Mus musculus (laboratory mouse) (0)

Xenopus tropicalis (Western clawed frog) (0)

Danio rerio (Zebrafish) (0)

Caenorhabditis elegans (Nematode, roundworm) (0)

Anopheles gambiae (African malaria mosquito) (1)

Agam\DH31

8 of 12

Yes

Arabidopsis thaliana (thale-cress) (0)

Saccharomyces cerevisiae (Brewer's yeast) (0)

Schizosaccharomyces pombe (Fission yeast) (0)

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dh31. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (0)

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Pdf

suppressible

Dh31

(Kunst et al., 2014)

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0032048

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-33

Cytogenetic map

29D1-29D3

Sequence location

2L:8,491,868..8,506,845 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

29D1-29D3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

2-33

(FlyBase, 2016)

2-28.2

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (93)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

68214

w^*, P{UAS-Dh31.t.ML}1

51988

w¹¹¹⁸; P{Dh31-GAL4.TH}2M

51989

P{Dh31-GAL4.TH}5F, w¹¹¹⁸

84490

w^*; TI{TI}Dh31^attP

46389

w¹¹¹⁸; P{GMR57F07-GAL4}attP2

47885

w¹¹¹⁸; P{GMR19F09-GAL4}attP2

48870

w¹¹¹⁸; P{GMR20A02-GAL4}attP2

48890

w¹¹¹⁸; P{GMR20D02-GAL4}attP2

48936

w¹¹¹⁸; P{GMR21C09-GAL4}attP2

48947

w¹¹¹⁸; P{GMR21E02-GAL4}attP2

VDRC

v37763

w¹¹¹⁸; P{GD4601}v37763

v50295

w¹¹¹⁸ P{GD16889}v50295

More stocks available...

Genomic Clones (23)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (21)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

AF171803

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0032048

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0032048

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Kurogi et al., 2023, Lin et al., 2022, Kunst et al., 2014, Park et al., 2008)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Dh31 acts as a circadian wake-promoting signal that awakens the fly in anticipation of dawn. Pdf protein secreted by the ventral pacemaker subset of circadian clock neurons acts on Pdf receptors in the Dh31-expressing dorsal clock neurons to increase Dh31 secretion before dawn.

(Kunst et al., 2014)

Dh31 peptide stimulates fluid secretion by Malpighian tubules.

(Coast et al., 2001)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG13094 anon- EST:Posey114

(Bayraktaroglu, 2000.11.2)

Source for merge of: Dh31 anon-WO02059370.45

(FlyBase, 1996-)

Additional comments

Source for merge of Dh31 anon-WO02059370.45 was sequence comparison ( date:051113 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (22)

Reported As

Symbol Synonym

CG13094

(Mao et al., 2024, National Institute of Genetics Fly Stocks, 2022-, Head et al., 2015, Asahina and Anderson, 2013.9.23, Lemaitre and Miguel-Aliaga, 2013, Reiher et al., 2011, Ni et al., 2010.12.1, Wegener and Gorbashov, 2008, Hewes and Taghert, 2001)

DH 31

(Park et al., 2008)

DH-II

(Johnson et al., 2004)

DH31

(Ahmad et al., 2025, Chen et al., 2025, Lee et al., 2025, Nässel, 2025, Yan et al., 2025, Yapici, 2025, Jiang et al., 2024, Liu et al., 2024, Lee et al., 2023, Manoli et al., 2023, Bajar et al., 2022, Najjar et al., 2022, Nässel and Zandawala, 2022, Ahmad et al., 2021, Barber et al., 2021, Dow et al., 2021, Khan et al., 2021, Koyama et al., 2021, Nässel, 2021, Shafer and Keene, 2021, Mazzotta et al., 2020, Nässel and Zandawala, 2020, Watnick and Jugder, 2020, Zhou et al., 2020, Deng et al., 2019, Gabilondo et al., 2018, Mandel et al., 2018, Nässel, 2018, Artiushin and Sehgal, 2017, Goda et al., 2016, Head et al., 2015, Kunst et al., 2015, Amcheslavsky et al., 2014, Kunst et al., 2014, Song et al., 2014, Vanderveken and O'Donnell, 2014, Duvall and Taghert, 2012, Nässel and Winther, 2010, Choi et al., 2009, Veenstra, 2009, Shafer et al., 2008, Veenstra et al., 2008, Johnson et al., 2005, Johnson et al., 2003)

DH₃₁

(Hector et al., 2009)

DH₃₁

(Mertens et al., 2005)

DH³¹

(Hallier et al., 2016)

Dh31

(Asahina and Zelikowsky, 2025, Lee et al., 2025, Liu et al., 2025, Medina et al., 2025, Nässel, 2025, Ren et al., 2025, Walsh et al., 2025, Xia and Li, 2025, Moriya et al., 2024, Tleiss et al., 2024, Chen et al., 2023, Goda et al., 2023, Kurogi et al., 2023, Lyu et al., 2023, Song et al., 2023, Deshpande et al., 2022, Dvořáček et al., 2022, Hung et al., 2021, Jin et al., 2021, Lee et al., 2021, Ma et al., 2021, Pang et al., 2021, Zhang et al., 2021, Hung et al., 2020, Koyama et al., 2020, Goda and Hamada, 2019, Goda et al., 2019, Hegazi et al., 2019, Rao and Deng, 2019.10.23, Ameku et al., 2018, Croset et al., 2018, Obniski et al., 2018, Schiemann et al., 2018, Takeda et al., 2018, Takeda et al., 2018, Abruzzi et al., 2017, Chen et al., 2017, Tomita et al., 2017, Transgenic RNAi Project members, 2017-, Chen et al., 2016, Crocker et al., 2016, Park et al., 2016, Lee et al., 2015, Bischof and FlyORF project members, 2014.6.20, Song et al., 2014, Asahina and Anderson, 2013.9.23, Lemaitre and Miguel-Aliaga, 2013, Marianes and Spradling, 2013, Caers et al., 2012, Ruben et al., 2012, Reiher et al., 2011, Lajeunesse et al., 2010, Hazelett et al., 2009, Wegener and Gorbashov, 2008)

Dh₃₁

(Birse et al., 2006)

Drm-DH₃₁

(Nassel, 2002, vanden Broeck, 2001)

Drome-DH₃₁

(Coast et al., 2001)

anon-EST:Posey114

anon-WO02059370.45

dh31

(Yildirim et al., 2022, Melcher and Pankratz, 2005)

drome-DH31

(O'Donnell et al., 2003)

Name Synonyms

Calcitonin

(Nässel and Winther, 2010)

Calcitonin-like diuretic hormone (31 residues)

(Nassel, 2002)

Diuretic Hormone 31

(Head et al., 2015, Asahina et al., 2014, Lajeunesse et al., 2010, Mertens et al., 2005)

Diuretic hormone 31

(Shafer, 2025, Tomita et al., 2017, Vanderveken and O'Donnell, 2014, Asahina and Anderson, 2013.9.23, Caers et al., 2012, Nässel and Winther, 2010, Veenstra et al., 2008, Johnson et al., 2005, Coast et al., 2001)

diuretic Hormone 31

(Hector et al., 2009)

diuretic hormone

(Amcheslavsky et al., 2014, Hewes and Taghert, 2001)

diuretic hormone 31

(Yadav et al., 2017, Owusu-Ansah and Perrimon, 2014, Veenstra, 2009, Birse et al., 2006, Johnson et al., 2004)

Secondary FlyBase IDs

FBgn0027765
FBgn0066015

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 32 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

34181

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VLK4

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VLK4

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q8IPF3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VLK4

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0032048

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

34181/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0032048

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0032048

FlyMine - An integrated database for Drosophila genomics

FBgn0032048

InterPro - A database of protein families, domains and functional sites

Diuretic hormone class 2-like

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG13094

MARRVEL_MODEL - MARRVEL (model organism gene)

34181

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0032048

DroID - A comprehensive database of gene and protein interactions.

FBgn0032048

DRSC - Results frm RNAi screens

FBgn0032048

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0032048

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0032048

Flygut - An atlas of the Drosophila adult midgut

FBgn0032048

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC004987

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (161)

The following external sites may use different assemblies or annotations than FlyBase.

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