FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Girdin2
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General Information
Symbol
Dmel\Girdin2
Species
D. melanogaster
Name
FlyBase ID
FBal0304748
Feature type
allele
Associated gene
Dmel\Girdin
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Houssin et al., 2015)
Mutagen
P-element activity
(Houssin et al., 2015)
Progenitor genotype
P{SUPor-P}GirdinKG07727
(Houssin et al., 2015)
Cytology
Description

Deletion that removes 364 bp of the Girdin 5' UTR and 75 bp of the open reading frame, including the initiation codon.

(Houssin et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:3,178,989..3,179,427 [+]
Comment:

Deletion resulting from the imprecise excision of P{SUPor-P}GirdinKG07727, which removes 364 bases of the Girdin 5' UTR and 75bp of the coding region.

(Houssin et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  carcinoma
      modeled by l(2)gl4
      (Biehler et al., 2020)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Homozygous embryos derived from females containing homozygous germline clones show defects in head morphogenesis and loss of anterior structures such as mouth hooks. They contain numerous ectopic granules of cuticle.

      (Houssin et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      Girdinc06007

      (Houssin et al., 2015)
      Rescued by

      Girdin2 is rescued by GirdinUAS.PA/Scer\GAL4da.PU

      (Houssin et al., 2015)
      Comments

      Expression of GirdinScer\UAS.PA under the control of Scer\GAL4da.PU rescues the lethality of Girdin2 animals.

      (Houssin et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Girdin2
      (Biehler et al., 2020, Houssin et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)