FlyBase Allele Report: Dmel\Tailor[c4-1]

General Information

Symbol

Dmel\Tailor^c4-1

Species

D. melanogaster

Name

FlyBase ID

FBal0314792

Feature type

allele

Associated gene

Dmel\Tailor

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Reimão-Pinto et al., 2015)

Mutagen

CRISPR/Cas9

(Reimão-Pinto et al., 2015)

Progenitor genotype

Cytology

Description

A 7bp deletion that results in a frame shift in the third exon of Tailor.

(Reimão-Pinto et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female semi-sterile (with Tailor^c4-6)

(Reimão-Pinto et al., 2015)

male semi-sterile (with Tailor^c4-6)

(Reimão-Pinto et al., 2015)

semi-fertile (with Tailor^f05717)

(Lin et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Tailor^f05717/Tailor^c4-1 transheterozygotes show significant decrease in both male and female fertility compared to controls.

(Lin et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Tailor^c4-1/Tailor^f05717 has semi-fertile phenotype, enhanceable by Dis3l2^SK5/Dis3l2^SK5

(Lin et al., 2017)

Enhancer of

Statement

Reference

Tailor^c4-1/Tailor^f05717 is an enhancer of semi-sterile phenotype of Dis3l2^SK5

(Lin et al., 2017)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The subfertility of Tailor^f05717/Tailor^c4-1 transheterozygous and Dis3l2^SK5 homozygous mutants is exacerbated further in double mutants and the Tailor^f05717/Tailor^c4-1;Dis3l2^SK5/Dis3l2^SK5 flies (males as well as females) are completely sterile.

(Lin et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Tailor^c4-1

Tailor[c4-1]

(Lin et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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