FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-124UAS.cWa
Open Close
General Information
Symbol
Dmel\mir-124UAS.cWa
Species
D. melanogaster
Name
FlyBase ID
FBal0316237
Feature type
allele
Associated gene
Dmel\mir-124
Associated Insertion(s)
Carried in Construct
P{UAS-mir-124.W}
Key Links
Transgenic product class
wild_type
(Wang et al., 2014)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Wang et al., 2014)
Mutagen
in vitro construct
(Wang et al., 2014)
Progenitor genotype
Carried in construct
P{UAS-mir-124.W}
Cytology
Description

UASt regulatory sequences drive expression of the 1191bp predicted pri-mir-124.

(Wang et al., 2014)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
mir-124
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Third instar larvae expressing mir-124Scer\UAS.cWa under the control of Scer\GAL4elav.PU show a significant reduction in branch length and the number of both type Ib and Is boutons at neuromuscular junction (NMJ) 6/7 compared to controls (significant differences to controls are not seen at NMJ 4).

      The ddaE and ddaF dendritic arborization neurons show a significant reduction in the number of dendritic branches in third instar larvae expressing mir-124Scer\UAS.cWa under the control of Scer\GAL4221.

      Flies expressing mir-124Scer\UAS.cWa under the control of Scer\GAL4elav.PU have a rough eye phenotype.

      (Wang et al., 2014)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      Scer\GAL4elav.PU/mir-124UAS.cWa partially rescues mir-124KO

      (Wang et al., 2014)
      Comments

      The reduced climbing and flight abilities of homozygous mir-124KO adults are partly rescued by expression of mir-124Scer\UAS.cWa under the control of Scer\GAL4elav.PU. The reduced fertility of homozygous mir-124KO females is also rescued.

      (Wang et al., 2014)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      mir-124Scer\UAS.cWa
      mir-124UAS.cWa
      Name Synonyms
      Secondary FlyBase IDs
        References (1)