FB2026_02 , released June 18, 2026
Allele: Dmel\Myo61F1
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General Information
Symbol
Dmel\Myo61F1
Species
D. melanogaster
Name
FlyBase ID
FBal0316572
Feature type
allele
Associated gene
Dmel\Myo61F
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Okumura et al., 2015)
Mutagen
Delta2-3 transposase
(Okumura et al., 2015)
Progenitor genotype
P{EP}Myo61FEP3325a
(Okumura et al., 2015)
Cytology
Description

Imprecise excision of the P{EP} element in P{EP}Myo61FEP3325a has resulted in a 3454bp deletion, removing the putative initiation codon and the region encoding the ATP-binding site in all the Myo61F isoforms. The expression of CG9184 is unaffected.

(Okumura et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:1,323,560..1,327,013 [+]
Comment:

3454 bp deletion resulting from the imprecise excision of the progenitor insertion. Genomic coorindates of deletion endpoints reported by author.

(Okumura et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The hatching rates and survival rates from first instar larvae to adult of homozygous Myo61F1 mutants (derived from homozygous Myo61F1 mutant females) are similar to those of wild type.

      Homozygous Myo61F1 mutants show normal left/right (l/r) asymmetric development in all sections of the embryonic gut.

      As in wild type, the 360[o] rotation that takes place in the male genitalia of homozygous Myo61F1 mutant flies during pupal development occurs in the dextral (right-handed) direction.

      (Okumura et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Myo61F1 is a non-enhancer of abnormal axis specification phenotype of Myo31DFL152

      (Okumura et al., 2015)

      Myo61F1/Myo95E1 is a non-enhancer of abnormal axis specification phenotype of Myo31DFL152

      (Okumura et al., 2015)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      Myo61F1 is an enhancer of male genitalia phenotype of Myo31DFK2

      (Okumura et al., 2015)

      Myo61F1/Myo95E1 is an enhancer of male genitalia phenotype of Myo31DFK2

      (Okumura et al., 2015)
      NOT Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Mutants that are doubly homozygous for Myo61F1 and Myo95E1 show normal left/right (l/r) asymmetric development in all sections of the embryonic gut.

      Neither homozygous Myo95E1 nor homozygous Myo61F1 enhances the frequency of left/right (l/r) inversion in the posterior midgut and the hindgut seen in homozygous Myo31DFL152 mutant embryos. As in homozygous Myo31DFL152 mutants alone, ~80% of the double mutants exhibit the l/r reversed phenotype. No further enhancement is seen in the homozygous Myo95E1, Myo61F1 and Myo31DFL152 triple mutants.

      As in wild type, the 360[o] rotation that takes place in the male genitalia of double homozygotic Myo95E1 Myo61F1 mutant flies during pupal development occurs in the dextral (right-handed) direction.

      Homozygous Myo61F1 enhances the change in direction of male genitalia rotation seen in Myo31DFK2 mutant pupae. As in Myo31DFK2 mutants alone, the double mutants undergo a left-handed (sinistral) rotation, rather than the 360% dextral (right-handed) rotation seen in wild type flies, but a greater proportion undergo a full 360[o] sinistral rotation in the presence of Myo61F1.

      Myo61F1/Df(3L)BSC250 enhances the change in direction of male genitalia rotation seen in Myo31DFK2 mutant pupae. As in Myo31DFK2 mutants alone, the double mutants undergo a left-handed (sinistral) rotation, rather than the 360% dextral (right-handed) rotation seen in wild type flies, but a greater proportion undergo a full 360[o] sinistral rotation in the presence of Myo61F1/Df(3L)BSC250.

      The presence of homozygous Myo61F1 and Myo95E1 mutations enhances the change in direction of male genitalia rotation seen in Myo31DFK2 mutant pupae. As in Myo31DFK2 mutants alone, the triple mutants undergo a left-handed (sinistral) rotation, rather than the 360[o] dextral (right-handed) rotation seen in wild type flies, but a greater proportion undergo a full 360[o] sinistral rotation in the presence of Myo61F1 and Myo95E1 mutations.

      (Okumura et al., 2015)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Myo61F1
      Name Synonyms
      Secondary FlyBase IDs
        References (1)