FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\SNCAA53T.UAS.cUa
Open Close
General Information
Symbol
Hsap\SNCAA53T.UAS.cUa
Species
H. sapiens
Name
FlyBase ID
FBal0316591
Feature type
allele
Associated gene
Hsap\SNCA
Associated Insertion(s)
Carried in Construct
P{UAS-SNCA.A53T.U}
Also Known As
UAS-SNCAA53T, UAS-A53T
Key Links
Transgenic product class
missense_variant
(FlyBase Curators, 2025-)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(FlyBase Curators, 2025-)
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-SNCA.A53T.U}
Cytology
Description

UAS regulatory sequences drive expression of an A53T mutant of Hsap\SNCA.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsap\SNCA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      model of  Parkinson's disease 1
      is ameliorated by Hsap\TMEM59UAS.cLa
      (Zhang et al., 2018)
      is ameliorated by ShEKO.UAS.GFP(GL)
      (Qi et al., 2017)
      is ameliorated by MiroKK102189
      (Shaltouki et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (FlyBase Curators, 2025-)
      SNCA:p.Ala53Thr
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      Associated human disease model(s)
      External database links
      ClinVar: SNCA_14007
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of Hsap\SNCAA53T.Scer\UAS.cUa under the control of Scer\GAL4ple.PU does not lead to any significant decrease in the number of dopaminergic neurons from the PPM1/2 cluster in young (3 and 10 days old) adult flies.

      (Song et al., 2017)

      Expression of Hsap\SNCAA53T.Scer\UAS.cUa under the control of Scer\GAL4Act.PU results in climbing defects, but does not significantly affect survival, as compared to controls.

      (Davis et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of Hsap\SNCAA53T.Scer\UAS.cUa with either auxGD7187 or auxKK100927 does not lead to any major decrease in the number of dopaminergic PPM1/2 neurons in the brains of young (3 and 10 days old) adult flies.

      (Song et al., 2017)

      Df(3R)GBA1ΔTT/Df(3R)GBA1ΔTT rescues the climbing defects of flies expressing Hsap\SNCAA53T.Scer\UAS.cUa under the control of Scer\GAL4Act.PU, but leads to decreased lifespan, as compared to controls.

      (Davis et al., 2016)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\SNCAA53T.Scer\UAS.cUa
      Hsap\SNCAA53T.UAS.cUa
      Name Synonyms
      Secondary FlyBase IDs
        References (12)