FlyBase Allele Report: Hsap\TMEM59[UAS.cLa]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Hsap\TMEM59^UAS.cLa

General Information

Symbol

Hsap\TMEM59^UAS.cLa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Liu

FlyBase ID

FBal0336716

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-hTMEM59.L}

Also Known As

UAS-Dcf1

Key Links

Transgenic product class

(Liu et al., 2017)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Liu et al., 2017)

Mutagen

in vitro construct

(Liu et al., 2017)

Progenitor genotype

Carried in construct

P{UAS-hTMEM59.L}

Cytology

Description

UAS regulates expression of Hsap\TMEM59.

(Liu et al., 2017)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease 1

modeled by Hsap\SNCA^A30P.UAS.cUa

(Zhang et al., 2018)

modeled by Hsap\SNCA^A53T.UAS.cUa

(Zhang et al., 2018)

modeled by Hsap\SNCA^UAS.cUa

(Zhang et al., 2018)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{C99.UAS.Exel.Tag:MYC}

(Li et al., 2020)

modeled by Hsap\APP^UAS.cUa, Hsap\BACE1^UAS.cUa

(Li et al., 2020)

exacerbates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.cUa}

(Li et al., 2021)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Hsap\TMEM59^UAS.cLa, Scer\GAL4^elav.PU is an enhancer of abnormal locomotor behavior | adult stage | progressive phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Li et al., 2021)

Hsap\TMEM59^UAS.cLa, Scer\GAL4^elav.PU is an enhancer of abnormal learning | adult stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Li et al., 2021)

Hsap\TMEM59^UAS.cLa, Scer\GAL4^elav.PU is an enhancer of abnormal memory | adult stage phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Li et al., 2021)

Phenotype Manifest In

Enhancer of

Statement

Reference

Hsap\TMEM59^UAS.cLa, Scer\GAL4^elav.PU is an enhancer of adult brain phenotype of Hsap\APP^{Aβ42.UAS.cUa}, Scer\GAL4^elav.PU

(Li et al., 2021)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Hsap\TMEM59^Scer\UAS.cLa

Hsap\TMEM59^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Liu

Secondary FlyBase IDs

References (4)

Report Sections