FlyBase Allele Report: Dmel\Tet[2]

General Information

Symbol

Dmel\Tet²

Species

D. melanogaster

Name

FlyBase ID

FBal0317026

Feature type

allele

Associated gene

Dmel\Tet

Associated Insertion(s)

Carried in Construct

Also Known As

DMAD², tet^DMAD2

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Zhang et al., 2015)

Mutagen

CRISPR/Cas9

(Zhang et al., 2015)

Progenitor genotype

Cytology

Description

1bp deletion within the Tet coding sequence.

(Zhang et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:2,795,011..2,795,011 [-]

Comment:

1bp deletion within the Tet coding sequence.

(Zhang et al., 2015)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

majority die during P-stage (with Tet¹)

(Zhang et al., 2015)

majority die during P-stage (with Tet^del-CD)

(Zhang et al., 2015)

short lived (with Tet¹)

(Zhang et al., 2015)

short lived (with Tet^del-CD)

(Zhang et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

Most Tet¹/Tet² mutant animals die at the pupal stage. A few escapers are able to pass through the pupal stage, but die within three days post-eclosion.

(Zhang et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

DMAD²

(He et al., 2019, Yao et al., 2018, Zhang et al., 2015)

Tet²

Tet^DMAD2

(Gerdy et al., 2025)

tet^DMAD2

(Boulet et al., 2023)

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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