FlyBase Allele Report: Dmel\Hasp[D1]

General Information

Symbol

Dmel\Hasp^D1

Species

D. melanogaster

Name

FlyBase ID

FBal0318093

Feature type

allele

Associated gene

Dmel\Hasp

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Nakayama et al., 2016)

Mutagen

P-element activity

(Nakayama et al., 2016)

Progenitor genotype

P{GSV2}GS7260

(Nakayama et al., 2016)

Cytology

Description

Deletion which spans the transcription start site and second exon of Hasp (the deletion removes the translation start codon). Generated by imprecise excision of the P{GSV2}GS7260 progenitor insertion.

(Nakayama et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Nakayama et al., 2016)

short lived

(Nakayama et al., 2016)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous adults are short lived (they all die by approximately 10 days after eclosion) and show severely reduced locomotion.

The microglomeruli in the mushroom body calyx are ultrastructurally normal in homozygous adults.

(Nakayama et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Hasp^D1 is rescued by Hasp^UAS.Tag:HA/Scer\GAL4^ChAT.PU

(Nakayama et al., 2016)

Hasp^D1 is rescued by Scer\GAL4^elav-C155/Hasp^UAS.Tag:HA

(Nakayama et al., 2016)

Hasp^D1 is rescued by Hasp^UAS.Tag:HA/Scer\GAL4^VGlut1.PU

(Nakayama et al., 2016)

Hasp^D1 is rescued by Hasp^UAS.Tag:HA/Scer\GAL4^5-HT1B.PU

(Nakayama et al., 2016)

Hasp^D1 is rescued by Hasp^UAS.Tag:HA/Scer\GAL4^Eaat1.PU

(Nakayama et al., 2016)

Hasp^D1 is rescued by Hasp^UAS.Tag:HA/Scer\GAL4^repo.PU

(Nakayama et al., 2016)

Hasp^D1 is rescued by Scer\GAL4^ple.PU/Hasp^UAS.Tag:HA

(Nakayama et al., 2016)

Partially rescued by

Hasp^D1 is partially rescued by Hasp^UAS.Tag:HA/Scer\GAL4^Ddc.PU

(Nakayama et al., 2016)

Comments

Expression of Hasp^{Scer\UAS.T:Ivir\HA1} under the control of any one of Scer\GAL4^ChAT.PU, Scer\GAL4^elav-C155, Scer\GAL4^VGlut.PU, Scer\GAL4^5-HT1B.PU, Scer\GAL4^Eaat1.PU or Scer\GAL4^repo.PU rescues the reduced longevity of homozygous Hasp^D1 adults.

Expression of Hasp^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Ddc.PU partially rescues the reduced longevity of homozygous Hasp^D1 adults.

Expression of one copy of Hasp^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^ple.PU partially rescues the reduced longevity of homozygous Hasp^D1 adults, while expression of two copies of Scer\GAL4^ple.PU results in full rescue.

(Nakayama et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hasp^D1

hasp^D1

(Nakayama et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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