FlyBase Allele Report: Dmel\bumpel[UAS.ORF.GW.Tag:HA]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\bumpel^{UAS.ORF.GW.Tag:HA}

General Information

Symbol

Dmel\bumpel^{UAS.ORF.GW.Tag:HA}

Species

D. melanogaster

Name

FlyBase ID

FBal0318175

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

M{UAS-bumpel.ORF.3xHA.GW}

Also Known As

UAS-bumpel

Key Links

Transgenic product class

(Bischof and FlyORF project members, 2014.6.20)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Bischof and FlyORF project members, 2014.6.20)

Mutagen

in vitro construct

(Bischof and FlyORF project members, 2014.6.20)

Progenitor genotype

Carried in construct

M{UAS-bumpel.ORF.3xHA.GW}

Cytology

Description

UAS regulatory sequences drive expression of a full-length CG6723 open reading frame (ORF) that is tagged at the C-terminal end with three copies of the Tag:HA epitope. The ORF is flanked by a pair of incompatible FRT sites (FRT5 and FRT2), which allows for future in vivo exchange of either the promoter or tag sequence.

(Bischof and FlyORF project members, 2014.6.20)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Tagged with

Also carries

recombinase target site

recombinase target site

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

modeled by Zzzz\poly-GR^PO-36.UAS

(Xu et al., 2023)

modeled by Zzzz\poly-PR^PO-36.UAS

(Xu et al., 2023)

modeled by Zzzz\poly-GA^PO-36.UAS

(Xu et al., 2023)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Xu et al., 2023)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

short lived | RU486 conditional, with Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

Atg1^HMS02750/bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO} is a non-enhancer of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Suppressor of

Statement

Reference

bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO} is a suppressor of short lived | RU486 conditional phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO} is a suppressor of decreased rate of adult locomotory behavior | progressive | RU486 conditional phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^{elav.Switch.PO}

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA} is a suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA} is a suppressor of increased rate of adult locomotory behavior | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Atg1^GS10797/bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO} is a suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA} is a suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-GR^PO-36.UAS

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA} is a suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-PR^PO-36.UAS

(Xu et al., 2023)

NOT Suppressor of

Statement

Reference

Atg1^HMS02750/bumpel^{UAS.ORF.GW.Tag:HA}, Scer\GAL4^{elav.Switch.PO} is a non-suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA} is a non-suppressor of short lived | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\poly-GA^PO-36.UAS

(Xu et al., 2023)

Phenotype Manifest In

Suppressor of

Statement

Reference

Scer\GAL4^{elav.Switch.PO}/bumpel^{UAS.ORF.GW.Tag:HA} is a suppressor of autolysosome | increased number | adult stage | RU486 conditional phenotype of Scer\GAL4^{elav.Switch.PO}, Zzzz\GGGGCC^36.UAS

(Xu et al., 2023)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

F003123

M{UAS-bumpel.ORF.3xHA.GW}ZH-86Fb

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG6723^{Scer\UAS.ORF.GW.T:Ivir\HA1}

CG6723^{UAS.ORF.GW.Tag:HA}

bumpel^{UAS.ORF.GW.Tag:HA}

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections