FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\mir-184KO.P
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General Information
Symbol
Dmel\mir-184KO.P
Species
D. melanogaster
Name
FlyBase ID
FBal0318382
Feature type
allele
Associated gene
Dmel\mir-184
Associated Insertion(s)
TI{TI}mir-184KO.P
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Peng et al., 2015)
Mutagen
ends-out gene targeting
(Peng et al., 2015)
Progenitor genotype
Associated Insertion(s)
TI{TI}mir-184KO.P
Cytology
Description

The sequence encoding the mir-184 pre-miRNA has been replaced with a loxP cassette that contains a w+mW.hs marker.

(Peng et al., 2015)
Allele components
Component
Use(s)
Also carries
loxP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The climbing speed of mir-184KO.P/mir-184KO.P flies is significantly slower than wild type. mir-184KO.P/mir-184KO.P third instar larvae have significantly reduced bouton numbers, significantly increased mini-bouton numbers and significantly increased bouton area at the neuromuscular junction compared to wild type. Distance between dbd and ddaA neurons is significantly increased in mir-184KO.P/mir-184KO.P embryos and third instar larvae.

      (Peng et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      mir-184KO.P is partially rescued by mir-184UAS.GFP/Scer\GAL4elav.PU

      (Peng et al., 2015)
      Comments

      Expression of mir-184Scer\UAS.T:Avic\GFP with a neuronal (Scer\GAL4elav.PU) driver rescues locomotor defect in mir-184KO.P/mir-184KO.P flies. Expression of mir-184Scer\UAS.T:Avic\GFP with a neuronal (Scer\GAL4elav.PU) driver rescues reduced bouton number and increased bouton area, and partially rescues increased mini-bouton number at the neuromuscular junction in mir-184KO.P/mir-184KO.P third instar larvae.

      (Peng et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      miR-184 KO
      (Peng et al., 2015)
      mir-184KO.P
      Name Synonyms
      Secondary FlyBase IDs
        References (1)