Abnormal wing posture, thoracic indentations, disruption of mitochondrial pattern in flight muscle and swollen mitochondria with fragmented inner membranes seen in Pink1B9/y males are partially suppressed by expression of cluScer\UAS.P\T.cSa driven by Scer\GAL4DJ667. Thoracic indentations seen in Pink1B9/y males are partially suppressed by expression of cluScer\UAS.P\T.cSa driven by Scer\GAL4Mhc.PW. Thoracic indentations seen in park25/park25 flies are not suppressed by expression of cluScer\UAS.P\T.cSa driven by Scer\GAL4Mhc.PW.
Expression of cluScer\UAS.P\T.cSa under the control of Scer\GAL4da.PU rescues the extremely short lifespan of clud08713 homozygote adults: practically all flies survive past post-eclosion day 5 and display longevity comparable to wild-type.
Expression of cluScer\UAS.P\T.cSa driven by Scer\GAL4da.PU rescues the mislocalization and clustering of mitochondria seen in germ cells in clud08713/clud08713 ovaries, as well as female sterility (egg-laying ability) and locomotor defects (climbing ability) in clud08713/clud08713 flies.