FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\CLUHUASp.cSa
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General Information
Symbol
Hsap\CLUHUASp.cSa
Species
H. sapiens
Name
FlyBase ID
FBal0318525
Feature type
allele
Associated gene
Hsap\CLUH
Associated Insertion(s)
Carried in Construct
P{UASp-CLUH.S}
Also Known As
UASp CLUH
Key Links
Transgenic product class
wild_type
(Sen et al., 2015)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Sen et al., 2015)
Mutagen
in vitro construct
(Sen et al., 2015)
Progenitor genotype
Carried in construct
P{UASp-CLUH.S}
Cytology
Description

UASp regulatory sequences drive expression of Hsap\CLUH.

(Sen et al., 2015)
Allele components
Component
Use(s)
Regulatory region(s)
UASp
Encoded product / tool
Hsap\CLUH
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  Parkinson's disease
      modeled by Pink1B9
      (Sen et al., 2015)
      DOES NOT ameliorate  Parkinson's disease
      modeled by park25
      (Sen et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mhc.PW/Hsap\CLUHUASp.cSa is a non-suppressor of visible phenotype of park25

      (Sen et al., 2015)
      Phenotype Manifest In
      Suppressor of
      NOT Suppressor of
      Statement
      Reference

      Scer\GAL4Mhc.PW/Hsap\CLUHUASp.cSa is a non-suppressor of mesonotum phenotype of park25

      (Sen et al., 2015)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Expression of Hsap\CLUHScer\UAS.P\T.cSa under the control of Scer\GAL4da.PU partially rescues both the pupariation delay and the extremely short lifespan of clud08713 homozygotes: majority of flies survive past post-eclosion day 5 and display longevity comparable to wild-type.

      (Sen and Cox, 2016)

      Expression of Hsap\CLUHScer\UAS.P\T.cSa driven by Scer\GAL4da.PU rescues the mislocalization and clustering of mitochondria seen in germ cells in clud08713/clud08713 ovaries, as well as female sterility (egg-laying ability) and locomotor defects (climbing ability) in clud08713/clud08713 flies.

      Thoracic indentations seen in Pink1B9/y males are partially suppressed by expression of Hsap\CLUHScer\UAS.P\T.cSa driven by Scer\GAL4Mhc.PW. Thoracic indentations seen in park25/park25 flies are not suppressed by expression of Hsap\CLUHScer\UAS.P\T.cSa driven by Scer\GAL4Mhc.PW.

      (Sen et al., 2015)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Hsap\CLUHScer\UAS.P\T.cSa
      Hsap\CLUHUASp.cSa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)