FB2026_02 , released June 18, 2026
Allele: Dmel\SCCROJ34
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General Information
Symbol
Dmel\SCCROJ34
Species
D. melanogaster
Name
FlyBase ID
FBal0319331
Feature type
allele
Associated gene
Dmel\SCCRO
Associated Insertion(s)
Carried in Construct
Key Links
Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Fu et al., 2016)
Mutagen
Delta2-3 transposase
(Fu et al., 2016)
Progenitor genotype
P{lacW}SCCROs1754
(Fu et al., 2016)
Cytology
Description

Deletion of the entire coding sequence of SCCRO. Generated by imprecise excision of P{lacW}SCCROs1754.

(Fu et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      SCCROJ34/SCCROJ34 flies show significant defects in upward migration when knocked to the bottom of a glass jar, compared to controls. SCCROJ34/SCCROJ34 third instar larvae show significant decreases in their response to touch compared to controls. SCCROJ34/SCCROJ34 flies have a shorter lifespan than controls. The average number of F1 progeny per breeding pair (female mutant, wild type male) is significantly reduced in SCCROJ34/SCCROJ34 mutants compared to controls. SCCROJ34/SCCROJ34 mutant clones generated in eye imaginal discs lead to the majority of mutant clones being eliminated from adult eyes (numbers are significantly reduced compared to wild type twin spots); whole mutant eye clones show significant decreases in eye size compared to controls. Mutant clones from third instar larval eye discs show increases in apoptosis, especially in cells close to clone boundaries.

      (Fu et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhanced by
      Statement
      Reference

      SCCROJ34 has short lived phenotype, enhanceable by SCCRO3J155/SCCRO3J155

      (Fu et al., 2016)
      Enhancer of
      Statement
      Reference

      SCCROJ34/SCCROJ34 is an enhancer of short lived phenotype of SCCRO3J155

      (Fu et al., 2016)
      Other
      Statement
      Reference

      SCCRO3J155, SCCROJ34 has female semi-sterile phenotype

      (Fu et al., 2016)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      SCCRO3J155/SCCRO3J155 SCCROJ34/SCCROJ34 double mutants have shorter lifespans and increased infertility compared to either single mutant (single mutants have shorter lifespans and decreased fertility compared to controls).

      (Fu et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      SCCROJ34 is rescued by Scer\GAL4unspecified/SCCROUAS.Tag:HA

      (Fu et al., 2016)
      Comments

      Expression of SCCROScer\UAS.T:Ivir\HA1 driven by Scer\GAL4unspecified rescues climbing ability defects in SCCROJ34/SCCROJ34 flies and decreases in touch sensitivity of SCCROJ34/SCCROJ34 third instar larvae.

      (Fu et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      J34
      (Fu et al., 2016)
      SCCROJ34
      Name Synonyms
      Secondary FlyBase IDs
        References (1)