FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\SCCROUAS.Tag:HA
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General Information
Symbol
Dmel\SCCROUAS.Tag:HA
Species
D. melanogaster
Name
FlyBase ID
FBal0319333
Feature type
allele
Associated gene
Dmel\SCCRO
Associated Insertion(s)
Carried in Construct
P{UAS-SCCRO.HA}
Key Links
Transgenic product class
wild_type
(Fu et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Fu et al., 2016)
Mutagen
in vitro construct
(Fu et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-SCCRO.HA}
Cytology
Description

UASt regulatory sequences drive expression of full-length SCCRO which is tagged at the N-terminal end with Tag:HA.

(Fu et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
SCCRO
Tagged with
Tag:HA
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Over-expression of a single copy of SCCROScer\UAS.T:Ivir\HA1 driven by Scer\GAL4GMR.PF at room temperature has no effect on eye development; over-expression of four copies results in large, bulging, rough eyes. Over-expression of SCCROScer\UAS.T:Ivir\HA1 driven by Scer\GAL4ptc.PU significantly increases cell number though there is no change in the distance between wing veins L3 and L4 due to significantly reduced cell size compared to controls. Over-expression of SCCROScer\UAS.T:Ivir\HA1 driven by Scer\GAL4ptc.PU leads to supernumerary macrochaetae on the notum. Clones from third instar larval eye discs with SCCROScer\UAS.T:Ivir\HA1 over-expression show increases in apoptosis in adjacent non-mutant cells.

      (Fu et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Co-expression of SCCROScer\UAS.T:Ivir\HA1 but not SCCRODAD.Scer\UAS suppresses the small rough eye phenotype and wing phenotypes seen in flies with expression of SCCRO4Scer\UAS.T:Hsap\MYC driven by Scer\GAL4GMR.PF. Co-expression of SCCROScer\UAS.T:Ivir\HA1 and SCCRO3Scer\UAS.T:Hsap\MYC leads to more severe eye phenotypes than seen with expression of SCCROScer\UAS.T:Ivir\HA1 or SCCRO3Scer\UAS.T:Hsap\MYC alone (driven by Scer\GAL4GMR.PF). Co-expression of SCCROScer\UAS.T:Ivir\HA1 and SCCRO3Scer\UAS.T:Hsap\MYC leads to significant increases in distance between L3 and L4 in the wing blade, along with significant increases in cell number (no changes in cell size) than is seen with expression of SCCROScer\UAS.T:Ivir\HA1 or SCCRO3Scer\UAS.T:Hsap\MYC alone (driven by Scer\GAL4ptc.PU).

      (Fu et al., 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4unspecified/SCCROUAS.Tag:HA rescues SCCROJ34

      (Fu et al., 2016)
      Comments

      Expression of SCCROScer\UAS.T:Ivir\HA1 driven by Scer\GAL4unspecified rescues climbing ability defects in SCCROJ156/SCCROJ156 flies and rescues decreases in touch sensitivity of SCCROJ34/SCCROJ34 or SCCROJ156/SCCROJ156 third instar larvae.

      (Fu et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      SCCROScer\UAS.T:Ivir\HA1
      SCCROUAS.Tag:HA
      Name Synonyms
      Secondary FlyBase IDs
        References (1)