FlyBase Allele Report: Dmel\Hrs[5-14-3]

General Information

Symbol

Dmel\Hrs^5-14-3

Species

D. melanogaster

Name

FlyBase ID

FBal0319595

Feature type

allele

Associated gene

Dmel\Hrs

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Sheng et al., 2016)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell death | somatic clone | third instar larval stage

(Sheng et al., 2016)

Phenotype Manifest In

eye disc | somatic clone | third instar larval stage

(Sheng et al., 2016)

wing disc | somatic clone | third instar larval stage

(Sheng et al., 2016)

Detailed Description

Statement

Reference

Somatic clones of Hrs^5-14-3/Hrs^5-14-3 cells in the third instar larval eye disc display low levels of apoptosis (detected by Caspase-3 staining).

(Sheng et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hrs^5-14-3 has increased cell death | third instar larval stage | somatic clone phenotype, enhanceable by Rbf^15aΔ/Rbf^15aΔ

(Sheng et al., 2016)

Enhancer of

Statement

Reference

Hrs^5-14-3/Hrs^5-14-3 is an enhancer of increased cell death | third instar larval stage | somatic clone phenotype of Rbf^15aΔ

(Sheng et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hrs^5-14-3 has eye disc | third instar larval stage | somatic clone phenotype, enhanceable by Rbf^15aΔ/Rbf^15aΔ

(Sheng et al., 2016)

Hrs^5-14-3 has wing disc | third instar larval stage | somatic clone phenotype, enhanceable by Rbf^15aΔ/Rbf^15aΔ

(Sheng et al., 2016)

Enhancer of

Statement

Reference

Hrs^5-14-3/Hrs^5-14-3 is an enhancer of eye disc | third instar larval stage | somatic clone phenotype of Rbf^15aΔ

(Sheng et al., 2016)

Hrs^5-14-3/Hrs^5-14-3 is an enhancer of wing disc | third instar larval stage | somatic clone phenotype of Rbf^15aΔ

(Sheng et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Somatic clones of Rbf^15aΔ;Hrs^5-14-3 double homozygous cells display significantly higher levels of apoptosis in third instar larval wing and eye discs, even in clones posterior to the eye disc morphogenetic furrow, compared to clones homozygous for either Rbf^15aΔ or Hrs^5-14-3 alone.

(Sheng et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Hrs^D28

(Sheng et al., 2016)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hrs^5-14-3

hrs^5-14-3

(Sheng et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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