FlyBase Allele Report: Dmel\Drice[L1]

General Information

Symbol

Dmel\Drice^L1

Species

D. melanogaster

Name

FlyBase ID

FBal0319652

Feature type

allele

Associated gene

Dmel\Drice

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

loss of function allele

(Wu et al., 2016)

Mutagen

ethyl methanesulfonate

(Wu et al., 2016)

Progenitor genotype

Cytology

Description

Amino acid replacement: Y86N.

(Wu et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:29,800,153..29,800,153 [+]

Nucleotide change:

T29800153A

Amino acid change:

Y86N | Drice-PA

Reported amino acid change:

Y86N

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Wu et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable

(Wu et al., 2016)

visible

(Wu et al., 2016)

Phenotype Manifest In

wing

(Wu et al., 2016)

Detailed Description

Statement

Reference

Drice^L1/Drice^L1 flies are viable and have wing clearance defects (similar to those seen in Drice¹⁷ or Drice^Δ1).

(Wu et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Drice^L1/Drice¹⁷ is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice[+]/Drice^L1 is a suppressor of visible phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^Δ1/Drice^L1 is a suppressor of visible phenotype of rpr^GMR.PW

(Wu et al., 2016)

Drice[+]/Drice^L1 is a suppressor of visible phenotype of rpr^GMR.PW

(Wu et al., 2016)

Drice[+]/Drice^L1 is a suppressor of increased cell death | larval stage phenotype of rpr^GMR.PW

(Wu et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Drice^L1/Drice¹⁷ is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice[+]/Drice^L1 is a suppressor of eye phenotype of hid^GMR.PG

(Wu et al., 2016)

Drice^Δ1/Drice^L1 is a suppressor of eye phenotype of rpr^GMR.PW

(Wu et al., 2016)

Drice[+]/Drice^L1 is a suppressor of eye phenotype of rpr^GMR.PW

(Wu et al., 2016)

Drice[+]/Drice^L1 is a suppressor of eye disc | larval stage phenotype of rpr^GMR.PW

(Wu et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Drice¹⁷/Drice^L1 (but not Drice¹⁷/+) significantly suppresses the eye ablation phenotype in hid^GMR.PG flies. Drice^Δ1/Drice^L1 (but not Drice^Δ1/+) significantly suppresses the eye ablation phenotype in rpr^GMR.PW flies. Drice^L1/+ weakly suppresses the eye ablation phenotype in rpr^GMR.PW or hid^GMR.PG flies. Drice^L1/+ significantly suppresses the increased cell death seen in rpr^GMR.PW larval eye discs.

(Wu et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Drice^L1

drICE^L1

(Wu et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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