FB2026_02 , released June 18, 2026
Allele: Dmel\TrehX-2
Open Close
General Information
Symbol
Dmel\TrehX-2
Species
D. melanogaster
Name
FlyBase ID
FBal0319701
Feature type
allele
Associated gene
Dmel\Treh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
TALEN
(Volkenhoff et al., 2015)
Progenitor genotype
Cytology
Description

6bp deletion within Treh, resulting in a frameshift that causes a premature stop codon affecting all predicted isoforms.

(Volkenhoff et al., 2015)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:21,085,473..21,085,484 [+]
Comment:

CRISPR-induced 12 bp deletion and insertion of 'GTTA' within Treh causing a frameshift and early translation termination.

Inserted_sequence:

GTTA

(Volkenhoff et al., 2015)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      TrehX-2 is rescued by TrehTag:HA

      (Volkenhoff et al., 2015)
      Comments

      Two copies of TrehT:Ivir\HA1 are needed to rescue lethality in TrehX-2/TrehX-2 mutants.

      (Volkenhoff et al., 2015)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      TrehX-2
      (Volkenhoff et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)