FlyBase Allele Report: Dmel\Drs[UAS.cUa]

General Information

Symbol

Dmel\Drs^UAS.cUa

Species

D. melanogaster

Name

Saccharomyces cerevisiae UAS construct a of Unknown

FlyBase ID

FBal0319749

Feature type

allele

Associated gene

Dmel\Drs

Associated Insertion(s)

Carried in Construct

P{UAS-Drs.U}

Also Known As

UAS-Drosomycin

Key Links

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(FlyBase Curators, 2025-)

Mutagen

in vitro construct

(FlyBase Curators, 2025-)

Progenitor genotype

Carried in construct

P{UAS-Drs.U}

Cytology

Description

UAS regulates expression of Drs.

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Drs

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of neurodegenerative disease

CEA

(Cao et al., 2013)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^elav.PU

(Cao et al., 2013)

abnormal neuroanatomy | adult stage | progressive, with Scer\GAL4^repo.PU

(Cao et al., 2013)

Phenotype Manifest In

adult brain | adult stage | progressive, with Scer\GAL4^elav.PU

(Cao et al., 2013)

adult brain | adult stage | progressive, with Scer\GAL4^repo.PU

(Cao et al., 2013)

Detailed Description

Statement

Reference

Expression of Drs^Scer\UAS.cUa driven by Scer\GAL4^elav.PU or Scer\GAL4^repo.PU leads to age-dependent neurodegeneration (brains look similar to controls at 2 days old but at 25 days old vacuolar lesions are present).

(Cao et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Drs^UAS.cUa, Scer\GAL4^repo.PU has abnormal neuroanatomy | adult stage | progressive phenotype, non-suppressible by Rel^RNAi.UAS.cUa, Scer\GAL4^repo.PU

(Cao et al., 2013)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Drs^UAS.cUa, Scer\GAL4^repo.PU has adult brain | adult stage | progressive phenotype, non-suppressible by Rel^RNAi.UAS.cUa, Scer\GAL4^repo.PU

(Cao et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Rel^VDRC.cUa does not suppress age-dependent neurodegeneration in fly brains with Drs^Scer\UAS.cUa driven by Scer\GAL4^repo.PU.

(Cao et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Drs^Scer\UAS.cUa

Drs^UAS.cUa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Unknown

Secondary FlyBase IDs

References (4)

Report Sections

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