FlyBase Allele Report: Dmel\CCHa2-R[TAL-34]

General Information

Symbol

Dmel\CCHa2-R^TAL-34

Species

D. melanogaster

Name

FlyBase ID

FBal0320384

Feature type

allele

Associated gene

Dmel\CCHa2-R

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

TALEN

Nature of the Allele

Allele class

Mutagen

TALEN

(Sano et al., 2015)

Progenitor genotype

Cytology

Description

74bp deletion between nucleotides 901 to 974 of CCHa2-R. This produces a frameshift at amino acid residue 62, leading to a premature stop codon at the 89th amino acid residue.

(Sano et al., 2015)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal body size | male | third instar larval stage (with CCHa2-R^KO51-2)

(Sano et al., 2015)

abnormal body size | third instar larval stage (with CCHa2-R^KO51-2)

(Sano et al., 2015)

abnormal developmental rate (with CCHa2-R^KO51-2)

(Sano et al., 2015)

Phenotype Manifest In

Detailed Description

Statement

Reference

CCHa2-R^KO51-2/CCHa2-R^TAL-34 transheterozygote mutants weigh significantly less than control larvae from 72 to 108 hrs after egg laying (AEL) (although their feeding activity in mid-third larval instar is comparable to controls) but display rapid weight gain after 108 hrs AEL and surpass the wild-type weight at 120 hrs AEL. However, their weight later decreases again, resulting in pupa and adults of normal weight. CCHa2-R^KO51-2/CCHa2-R^TAL-34 transheterozygotes also display a marked developmental delay during the larval stages with the feeding period extended by about 24 hrs.

(Sano et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

CCHa2-R^KO51-2/CCHa2-R^TAL-34 has abnormal body size | male | third instar larval stage phenotype, suppressible by Df(3R)Exel7320

(Sano et al., 2015)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The rapid body weight gain observed in CCHa2-R^KO51-2/CCHa2-R^TAL-34 transheterozygote male larvae between 96 and 120 hrs after egg laying is suppressed by combination with Df(1)Ilp6-3932 in hemizygous state.

(Sano et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CCHa2-R^TAL-34

(Sano et al., 2015)

CCHa2-R^TAL34

(Hudry et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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