FlyBase Allele Report: Dmel\lt[LL07138]

General Information

Symbol

Dmel\lt^LL07138

Species

D. melanogaster

Name

FlyBase ID

FBal0320422

Feature type

allele

Associated gene

Dmel\lt

Associated Insertion(s)

PBac{SAstopDsRed}lt^LL07138

Carried in Construct

Also Known As

lt^LL, Lt[LL]

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Associated Insertion(s)

PBac{SAstopDsRed}lt^LL07138

Cytology

Description

Allele components

Component

Use(s)

Inserted element

PBac{SAstopDsRed}

gene trap

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2L:22,925,032..22,925,032 [+]

(Lőrincz et al., 2017, Lőrincz et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell size

(Lőrincz et al., 2019)

Phenotype Manifest In

autophagosome | increased number

(Lőrincz et al., 2019)

embryonic/larval garland cell | larval stage (with Df(2L)lt45)

(Lőrincz et al., 2016)

garland cell

(Lőrincz et al., 2019)

late endosome

(Lőrincz et al., 2019)

late endosome | larval stage (with Df(2L)lt45)

(Lőrincz et al., 2016)

vacuole | larval stage (with Df(2L)lt45)

(Lőrincz et al., 2016)

Detailed Description

Statement

Reference

lt^LL07138 garland cells are enlarged and show smaller late endosomes (Rab7-positive puncta) and increased numbers of autophagosomes (endogenous Atg8a-positive puncta), as compared to controls.

(Lőrincz et al., 2019)

lt^LL07138/Df(2L)lt45 mutant larvae do not exhibit hemocyte-derived melanotic tumors, but do exhibit enlargement of late endosomes and enlarged vacuoles with multiple dense cores in garland nephrocytes, as compared to controls.

(Lőrincz et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Df(2L)lt45/lt^LL07138 is a non-suppressor of melanotic mass phenotype | larval stage phenotype of Vps8¹/Df(3L)ED211

(Lőrincz et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

Df(2L)lt45/lt^LL07138 is an enhancer of embryonic/larval garland cell | larval stage phenotype of Vps8¹/Df(3L)ED211

(Lőrincz et al., 2016)

NOT Suppressor of

Statement

Reference

Df(2L)lt45/lt^LL07138 is a non-suppressor of late endosome | larval stage phenotype of Vps8¹/Df(3L)ED211

(Lőrincz et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

lt^LL07138/Df(2L)lt45, Vps8¹/Df(3L)ED211 double mutants exhibit similar melanotic tumor-formation and nephrocyte late endosome fragmentation phenotypes as compared to Vps8¹/Df(3L)ED211 single mutants, and nephrocytes also exhibit many small electron dense lysosome-like organelles.

(Lőrincz et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

lt^LL07138 is rescued by lt^UAS.Tag:HA/Scer\GAL4^pros.PU

(Lőrincz et al., 2019)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Kyoto

141970

y^* w^*; PBac{SAstopDsRed}lt^LL07138 P{neoFRT}40A P{FRT(w^hs)}G13 cn¹ bw¹ / CyO, S^* bw¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Lt^LL07138

(Takáts et al., 2021)

Lt[LL]

(Takáts et al., 2021)

lt^LL07138

(Lőrincz et al., 2019, Csizmadia et al., 2018, Lőrincz et al., 2017, Lőrincz et al., 2016)

lt^LL

(Lőrincz et al., 2016)

lt^ll

(Lőrincz et al., 2019)

lt[LL07138]

(Boda et al., 2019)

lt[LL]

(Boda et al., 2019)

Name Synonyms

Secondary FlyBase IDs

References (6)

Report Sections

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