FB2026_02 , released June 18, 2026
Allele: Dmel\NosΔN-ter
Open Close
General Information
Symbol
Dmel\NosΔN-ter
Species
D. melanogaster
Name
FlyBase ID
FBal0320750
Feature type
allele
Associated gene
Dmel\Nos
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Rabinovich et al., 2016)
Progenitor genotype
Cytology
Description

8595bp deletion that removes the first 5 coding exons of Nos (includes the oxygenase domain and glutamine-rich sequence that contributes to protein-protein interactions).

(Rabinovich et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A subset of NosΔN-ter/NosΔN-ter or NosΔall/NosΔN-ter mutants display pruning defects and/or precocious regrowth of axons in the mushroom body gamma-lobe, as compared to controls.

      NosΔN-ter/NosΔN-ter mushroom body clones do not display any obvious phenotype in gamma lobe innervation, as compared to controls.

      Expression of NosIVS.Syn21.p10.10xScer\UAS under the control of Scer\GAL4GMR71G10 in NosΔN-ter/NosΔN-ter mushroom body clones leads to a dramatic delay in axon regrowth in the gamma lobe.

      (Rabinovich et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      NOSter
      (Kozlov et al., 2020)
      NOSΔter
      (Kozlov et al., 2020)
      NosΔN-ter
      dNOSΔN-ter
      (Rabinovich et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)