FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TorsinRNAi.UAS.WIZ
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General Information
Symbol
Dmel\TorsinRNAi.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0321686
Feature type
allele
Associated gene
Dmel\Torsin
Associated Insertion(s)
Carried in Construct
P{UAS-Torsin.RNAi.WIZ.N}
Key Links
Transgenic product class
RNAi_reagent
(Nguyen et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Nguyen et al., 2016)
Mutagen
in vitro construct
(Nguyen et al., 2016)
Progenitor genotype
Carried in construct
P{UAS-Torsin.RNAi.WIZ.N}
Cytology
Description

UAS regulatory sequences drive expression of an inverted repeat of the first 500bp of the first exon and intron of Torsin.

(Nguyen et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Torsin
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4αTub84B.PL, Scer\GAL4C57 or Scer\GAL4elav-C155 results in significant increases in the number of type I boutons at the larval neuromuscular junction, compared to controls. Flies with expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4αTub84B.PL have shorter lifespans and show significant locomotor deficits starting at 3 days old and worsening with age compared to controls (or flies expressing TorsinScer\UAS.cNa). Flies with expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4C57 have significantly shorter lifespans than controls (but not compared to flies expressing TorsinScer\UAS.cNa) and show significant locomotor deficits starting at 3 days old and worsening with age. Flies with expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4elav-C155 have significantly shorter lifespans than controls but do not show consistent significant locomotor deficits even by day 12. Scer\GAL4αTub84B.PL>TorsindsRNA.Scer\UAS.WIZ flies treated with hydrogen peroxide show a significant increase in the hazardous ratio, but no difference in response to paraquat, compared to controls.

      (Nguyen et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Phenotype Manifest In
      NOT Enhancer of
      Statement
      Reference

      Scer\GAL4αTub84B.PL/TorsinRNAi.UAS.WIZ is a non-enhancer of type I bouton | larval stage phenotype of Fmr1Δ50M

      (Nguyen et al., 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      TorsinRNAi.UAS.WIZ
      TorsindsRNA.Scer\UAS.WIZ
      TorsindsRNA.UAS.WIZ
      Name Synonyms
      Secondary FlyBase IDs
        References (2)