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General Information
Symbol
Dmel\TorsindsRNA.UAS.WIZ
Species
D. melanogaster
Name
FlyBase ID
FBal0321686
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of an inverted repeat of the first 500bp of the first exon and intron of Torsin.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4αTub84B.PL, Scer\GAL4C57 or Scer\GAL4elav-C155 results in significant increases in the number of type I boutons at the larval neuromuscular junction, compared to controls. Flies with expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4αTub84B.PL have shorter lifespans and show significant locomotor deficits starting at 3 days old and worsening with age compared to controls (or flies expressing TorsinScer\UAS.cNa). Flies with expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4C57 have significantly shorter lifespans than controls (but not compared to flies expressing TorsinScer\UAS.cNa) and show significant locomotor deficits starting at 3 days old and worsening with age. Flies with expression of TorsindsRNA.Scer\UAS.WIZ driven by Scer\GAL4elav-C155 have significantly shorter lifespans than controls but do not show consistent significant locomotor deficits even by day 12. Scer\GAL4αTub84B.PL>TorsindsRNA.Scer\UAS.WIZ flies treated with hydrogen peroxide show a significant increase in the hazardous ratio, but no difference in response to paraquat, compared to controls.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Phenotype Manifest In
NOT Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
TorsindsRNA.Scer\UAS.WIZ
TorsindsRNA.UAS.WIZ
Name Synonyms
Secondary FlyBase IDs
    References (1)