FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Trehcs1
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General Information
Symbol
Dmel\Trehcs1
Species
D. melanogaster
Name
FlyBase ID
FBal0321690
Feature type
allele
Associated gene
Dmel\Treh
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Yoshida et al., 2016)
Progenitor genotype
Cytology
Description

10bp deletion in Treh, producing a premature stop codon which is predicted to result in a lack of the entire catalytic domain.

(Yoshida et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
2R:21,085,542..21,085,551 [+]
Comment:

A 10bp deletion in Treh causes a frameshift and leads to early translation termination.

(Yoshida et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Trehcs1/Trehcs1 and Trehcs1/Df(2R)Exel6072, but not Trehcs1/+, mutants exhibit lethality during pupal stage. Trehcs1/Trehcs1 and Trehcs1/Df(2R)Exel6072 mutants exhibit significantly increased trehalose and decreased glucose levels, but no significant difference in glycogen or TAG levels in third instar larvae, as compared to controls. Trehcs1/Trehcs1 mutant larvae display significantly decreased survival and increased trehalose in response to starvation, but do not show significant changes in glycogen levels in response to starvation or desiccation, as compared to controls; Trehcs1/Trehcs1, but not Trehcs1/+, mutant larvae exhibit a significant increase in hemolymph volume, and display significantly decreased viability after desiccation stress, as compared to controls.

      (Yoshida et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      Trehcs1 is a non-enhancer of abnormal developmental rate phenotype of Tps1k08903

      (Nishimura, 2020)
      NOT Suppressor of
      Statement
      Reference

      Trehcs1 is a non-suppressor of abnormal developmental rate phenotype of Tps1k08903

      (Nishimura, 2020)
      Other
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Trehcs1
      (Kazek et al., 2024, Nishimura, 2020, Yoshida et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)