FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AblΔCR1.EGFP
Open Close
General Information
Symbol
Dmel\AblΔCR1.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0321745
Feature type
allele
Associated gene
Dmel\Abl
Associated Insertion(s)
Carried in Construct
PBac{Abl-GFP.ΔCR1}
Also Known As
AblΔCR1
Key Links
Transgenic product class
inframe_deletion
(Rogers et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Rogers et al., 2016)
Mutagen
in vitro construct
(Rogers et al., 2016)
Progenitor genotype
Carried in construct
PBac{Abl-GFP.ΔCR1}
Cytology
Description

2kb of upstream Abl promoter sequence drives expression of a mutated Abl coding region, which lacks conserved region 1 (amino acid residues 734-789 are deleted). The protein is tagged at the C-terminal end with EGFP.

(Rogers et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
Abl
Encoded product / tool
Abl
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      A few maternal-zygotic stage 15 AblΔCR1.EGFP embryos display a range of CNS defects, from moderate axon patterning defects with frequent loss of commissures to more severe axon patterning defects.

      (Spracklen et al., 2019)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      AblΔCR1.EGFP partially rescues Abl4

      (Rogers et al., 2021)

      AblΔCR1.EGFP partially rescues Abl4/Df(3L)st-j7

      (Rogers et al., 2016)

      AblΔCR1.EGFP partially rescues Abl4

      (Rogers et al., 2016)
      Comments

      The near complete pupal lethality of Abl4/Df(3L)st-j7 animals is partially rescued by combination with AblΔCR1.T:Avic\GFP-EGFP, strongly restoring adult viability at 25 but only weakly at 18[o]C. It partially rescues the almost embryonic lethality and embryonic morphogenesis defects of progeny from Abl4/Df(3L)st-j7 mothers.

      AblΔCR1.T:Avic\GFP-EGFP also partially rescues the lethality and to varying degrees also the multiple embryonic morphogenesis defects of progeny from females whose germlines are homozygous for Abl4 (created using the FLP/FRT/DFS system): the defective cellularization and disrupted axon scaffold at the ventral nerve cord as well as dorsal closure (uneven leading edge, zippering defects or aberrant shapes of cells at the leading edge) are weakly, while mesoderm invagination is strongly rescued.

      (Rogers et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      AblΔCR1.EGFP
      AblΔCR1.T:Avic\GFP-EGFP
      AblΔCR1
      (Spracklen et al., 2019)
      Name Synonyms
      Secondary FlyBase IDs
        References (3)