FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AblΔCR4.EGFP
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General Information
Symbol
Dmel\AblΔCR4.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0321748
Feature type
allele
Associated gene
Dmel\Abl
Associated Insertion(s)
Carried in Construct
PBac{Abl-GFP.ΔCR4}
Key Links
Transgenic product class
inframe_deletion
(Rogers et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Rogers et al., 2016)
Mutagen
in vitro construct
(Rogers et al., 2016)
Progenitor genotype
Carried in construct
PBac{Abl-GFP.ΔCR4}
Cytology
Description

2kb of upstream Abl promoter sequence drives expression of a mutated Abl coding region, which lacks conserved region 4 (amino acid residues 1063-1095 are deleted). The protein is tagged at the C-terminal end with EGFP.

(Rogers et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
Abl
Encoded product / tool
Abl
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescues

      AblΔCR4.EGFP partially rescues Abl4/Df(3L)st-j7

      (Rogers et al., 2016)

      AblΔCR4.EGFP partially rescues Abl4

      (Rogers et al., 2016)
      Comments

      The near complete pupal lethality of Abl4/Df(3L)st-j7 animals is strongly rescued by combination with AblΔCR4.T:Avic\GFP-EGFP, restoring adult viability at 25[o]C and to a lesser extent also at 18[o]C. It rescues the almost complete embryonic lethality of progeny from Abl4/Df(3L)st-j7 mothers and partially rescues lethality of progeny from females whose germlines are homozygous for Abl4 (created using the FLP/FRT/DFS system).

      (Rogers et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AblΔCR4.EGFP
      AblΔCR4.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (1)