FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\AblΔFABD.EGFP
Open Close
General Information
Symbol
Dmel\AblΔFABD.EGFP
Species
D. melanogaster
Name
FlyBase ID
FBal0321749
Feature type
allele
Associated gene
Dmel\Abl
Associated Insertion(s)
Carried in Construct
PBac{Abl-GFP.ΔFABD}
Also Known As
AblΔFABD
Key Links
Transgenic product class
inframe_deletion
(Rogers et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Rogers et al., 2016)
Mutagen
in vitro construct
(Rogers et al., 2016)
Progenitor genotype
Carried in construct
PBac{Abl-GFP.ΔFABD}
Cytology
Description

2kb of upstream Abl promoter sequence drives expression of a mutated Abl coding region, which lacks the F-actin-binding domain (amino acid residues 1418-1520 are deleted). The protein is tagged at the C-terminal end with EGFP.

(Rogers et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
Abl
Encoded product / tool
Abl
Tagged with
EGFP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      AblΔFABD.EGFP rescues Abl4

      (Rogers et al., 2021)
      Partially rescues

      AblΔFABD.EGFP partially rescues Abl4/Df(3L)st-j7

      (Rogers et al., 2016)

      AblΔFABD.EGFP partially rescues Abl4

      (Rogers et al., 2016)
      Comments

      The near complete pupal lethality of Abl4/Df(3L)st-j7 animals is partially rescued by combination with AblΔFABD.T:Avic\GFP-EGFP, strongly restoring adult viability at both 25 and 18[o]C. It rescues the the almost complete embryonic lethality and embryonic morphogenesis defects of progeny from Abl4/Df(3L)st-j7 mothers, yielding viable and fertile adults.

      AblΔFABD.T:Avic\GFP-EGFP also partially rescues the lethality and to varying degrees also the multiple embryonic morphogenesis defects of progeny from females whose germlines are homozygous for Abl4 (created using the FLP/FRT/DFS system): the defective cellularization, mesoderm invagination and dorsal closure (uneven leading edge, zippering defects or aberrant shapes of cells at the leading edge) are strongly rescued, but the disrupted axon scaffold at the embryonic ventral nerve cord less so.

      (Rogers et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      AblΔFABD.EGFP
      AblΔFABD.T:Avic\GFP-EGFP
      Name Synonyms
      Secondary FlyBase IDs
        References (2)