FlyBase Allele Report: Hsap\HSPA1L[UAS.sec]

General Information

Symbol

Hsap\HSPA1L^UAS.sec

Species

H. sapiens

Name

FlyBase ID

FBal0322575

Feature type

allele

Associated gene

Hsap\HSPA1L

Associated Insertion(s)

Carried in Construct

P{UAS-hHSPA1L.sec}

Key Links

Transgenic product class

wild_type

(Fernandez-Funez et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Fernandez-Funez et al., 2016)

Mutagen

in vitro construct

(Fernandez-Funez et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-hHSPA1L.sec}

Cytology

Description

UAS regulatory sequences drive expression of the human Ig heavy chain V-III signal peptide followed by the Hsap\HSPA1L open reading frame. The resulting protein is secreted into the extracellular space.

(Fernandez-Funez et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Hsap\HSPA1L

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Alzheimer's disease

modeled by Hsap\APP^2xAPP.SP.UAS

(Fernandez-Funez et al., 2016)

modeled by Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Fernandez-Funez et al., 2016)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^2xAPP.SP.UAS

(Martín-Peña et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Flies expressing Hsap\HSPA1L^Scer\UAS.sec under the control of Scer\GAL4^GMR.PU do not exhibit any obvious eye phenotypes.

(Fernandez-Funez et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor of increased cell death | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 is a suppressor | partially of increased cell death | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor of abnormal size | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor | partially of increased cell death | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^elav.PU is a suppressor | partially of abnormal locomotor behavior | progressive phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^elav.PU is a suppressor | partially of short lived phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^elav.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec/Scer\GAL4^repo.PU is a suppressor of visible | adult stage phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor of visible | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

NOT Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a non-suppressor of visible | adult stage phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 has abnormal neuroanatomy | adult stage phenotype

(Fernandez-Funez et al., 2016)

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 has abnormal size | adult stage phenotype

(Fernandez-Funez et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.sec/Scer\GAL4^repo.PU is a suppressor of eye phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec/Scer\GAL4^repo.PU is a suppressor of ommatidium | adult stage phenotype of Hsap\APP^{Aβ42.GMR.Tag:SS(rPENK)}

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor of ommatidium | adult stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor of lens phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a suppressor | partially of eye disc posterior compartment | larval stage phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 is a suppressor | partially of Kenyon cell phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 is a suppressor | partially of axon phenotype of Hsap\APP^2xAPP.SP.UAS, Scer\GAL4^ey-OK107

(Fernandez-Funez et al., 2016)

NOT Suppressor of

Statement

Reference

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a non-suppressor of eye phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Hsap\HSPA1L^UAS.sec, Scer\GAL4^GMR.PU is a non-suppressor of lens phenotype of Hsap\ATXN3^{tr.Q78.UAS.Tag:HA}, Scer\GAL4^GMR.PU

(Fernandez-Funez et al., 2016)

Other

Statement

Reference

Hsap\APP^2xAPP.SP.UAS, Hsap\HSPA1L^UAS.sec, Scer\GAL4^ey-OK107 has calyx of adult mushroom body phenotype

(Fernandez-Funez et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Expression of Hsap\HSPA1L^Scer\UAS.sec under the control of Scer\GAL4^repo.PU suppresses the ommatidial fusion phenotype seen in flies expressing two copies of Hsap\APP^Aβ42.GMR.

Co-expression of Hsap\HSPA1L^Scer\UAS.sec partially suppresses the locomotor defects and reduced lifespan of flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^elav.PU.

Co-expression of Hsap\HSPA1L^Scer\UAS.sec partially suppresses the increased cell death observed in adult Kenyon cells of the mushroom body, and enhances the increased size of the calyx at 1 day old, suppresses the thin Kenyon cell axons, and suppresses the decreased size of the calyx at 20 and 40 days old in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^ey-OK107.

Co-expression of Hsap\HSPA1L^Scer\UAS.sec completely suppresses the eye phenotypes of adult flies, and partially suppresses the increased cell death observed in larval posterior eye discs in flies expressing Hsap\APP^{2xAPP.SP.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

Co-expression of Hsap\HSPA1L^Scer\UAS.sec fails to suppress the eye phenotypes of flies expressing Hsap\ATXN3^{tr.Q78.Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU.

(Fernandez-Funez et al., 2016)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\HSPA1L^Scer\UAS.sec

Hsap\HSPA1L^UAS.sec

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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