FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TyrRGal4
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General Information
Symbol
Dmel\TyrRGal4
Species
D. melanogaster
Name
FlyBase ID
FBal0322958
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Progenitor genotype
Associated Insertion(s)
Cytology
Description

Approximately 0.7kb of the TyrR coding region, corresponding to the N-terminal region and first two transmembrane domains, has been replaced with sequence encoding a GAL4 driver and a w+mW.hs marker.

Allele components
Component
Use(s)
Inserted element
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

TyrRGal4 homozygous adult males display strong increase in male-male courtship - both toward other males of the same genotype (multiple males chase each other and form chains of courting males) and toward wild-type in single pair trials. The gender preference of TyrRGal4 males toward either decapitated wild-type male/female targets or toward live fruP1.LexA/fru4-40 male (these males do not court females) and wild-type female in choice assays is not changed compared to controls and strongly biased for females. However, when presented with a fruP1.LexA/fru4-40 male alone, TyrRGal4 males show strong courtship response to these males as well. Paired with a virgin wild-type female, TyrRGal4 males display same courtship initiation latencies and copulation durations as controls and they also show decrease (rather than increase) in aggression and locomotion, suggesting no general increase in arousal. TyrRGal4 males display nearly maximal courtship indices toward females regardless of their age - unlike the controls that court mid-aged females more intensely than very young or older ones. TyrRGal4 homozygote females exhibit normal post-mating behaviors (decreased receptivity and remating and increased egg laying).

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

The increased level of male-male courtship characteristic for TyrRGal4 homozygotes is rescued by combination with TyrR+tCH322-156H15 or by co-expression of TyrRScer\UAS.cHa.

Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Name Synonyms
Secondary FlyBase IDs
    References (2)