FlyBase Allele Report: Dmel\Psc[N1.UAS.Tag:MYC]

General Information

Symbol

Dmel\Psc^{N1.UAS.Tag:MYC}

Species

D. melanogaster

Name

FlyBase ID

FBal0323594

Feature type

allele

Associated gene

Dmel\Psc

Associated Insertion(s)

Carried in Construct

P{UAS-Psc.N1.Myc}

Key Links

Transgenic product class

inframe_deletion

(Li et al., 2016)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

inframe_deletion

(Li et al., 2016)

Mutagen

in vitro construct

(Li et al., 2016)

Progenitor genotype

Carried in construct

P{UAS-Psc.N1.Myc}

Cytology

Description

UAS regulatory sequences drive expression of truncated Psc (C-terminal region removed), tagged with Tag:MYC.

(Li et al., 2016)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

Psc

Tagged with

Tag:MYC

epitope tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

increased cell number | adult stage | female, with Scer\GAL4^C587

(Li et al., 2016)

neoplasia | adult stage | female, with Scer\GAL4^C587

(Li et al., 2016)

Phenotype Manifest In

germarium, with Scer\GAL4^C587

(Li et al., 2016)

Detailed Description

Statement

Reference

Expression of Psc^{N1.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^C587 (together with tub-Gal80[ts] to limit the time of expression to adulthood) does not cause any obvious defects in germaria morphology and development when expressed for 7 days only but cause accumulation of germline stem cell-like cells (which increases with age) when expressed for 2 weeks.

(Li et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Psc^{N1.UAS.Tag:MYC}, Scer\GAL4^C587 has increased cell number | adult stage | female phenotype, enhanceable by Su(z)2^{N1.UAS.Tag:MYC}, Scer\GAL4^C587

(Li et al., 2016)

Psc^{N1.UAS.Tag:MYC}, Scer\GAL4^C587 has neoplasia | adult stage | female phenotype, enhanceable by Su(z)2^{N1.UAS.Tag:MYC}, Scer\GAL4^C587

(Li et al., 2016)

Enhancer of

Statement

Reference

Psc^{N1.UAS.Tag:MYC}, Scer\GAL4^C587 is an enhancer of increased cell number | adult stage | female phenotype of Scer\GAL4^C587, Su(z)2^{N1.UAS.Tag:MYC}

(Li et al., 2016)

Psc^{N1.UAS.Tag:MYC}, Scer\GAL4^C587 is an enhancer of neoplasia | adult stage | female phenotype of Scer\GAL4^C587, Su(z)2^{N1.UAS.Tag:MYC}

(Li et al., 2016)

Phenotype Manifest In

Enhanced by

Statement

Reference

Psc^{N1.UAS.Tag:MYC}, Scer\GAL4^C587 has germarium phenotype, enhanceable by Su(z)2^{N1.UAS.Tag:MYC}, Scer\GAL4^C587

(Li et al., 2016)

Enhancer of

Statement

Reference

Psc^{N1.UAS.Tag:MYC}, Scer\GAL4^C587 is an enhancer of germarium phenotype of Scer\GAL4^C587, Su(z)2^{N1.UAS.Tag:MYC}

(Li et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

The accumulation of germline stem cell-like cells in the adult female germaria observed upon 2-week (but not shorter) expression of Psc^{N1.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^C587 (together with tub-Gal80[ts] to limit the time of expression to adulthood) develops much sooner (after one week only) when Psc^{N1.Scer\UAS.T:Hsap\MYC} is expressed simultaneously with Su(z)2^{N1.Scer\UAS.T:Hsap\MYC}, however no obvious increase in apoptosis is observed.

(Li et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

68152

w^*; P{UAS-Psc.N1.Myc}2

68225

w^*; P{UAS-Psc.N1.Myc}2, P{UAS-Su(z)2.N1.Myc}2/CyO

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Psc^{N1.Scer\UAS.T:Hsap\MYC}

Psc^{N1.UAS.Tag:MYC}

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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