FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\hhAC2
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General Information
Symbol
Dmel\hhAC2
Species
D. melanogaster
Name
FlyBase ID
FBal0324764
Feature type
allele
Associated gene
Dmel\hh
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        hhAC2/hhts2 transheterozygote females (moved to the non-permissive temperature - 29[o]C - after eclosion) show a moderate tumorous phenotype with numerous ectopic germline stem cell/cystoblast-like cells in a portion of the adult germaria.

        (Li et al., 2015)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        Statement
        Reference

        hhAC2/hhts2 has neoplasia | adult stage | female | temperature conditional phenotype, enhanceable by Scer\GAL4C587/hpoUAS.cWa

        (Li et al., 2015)
        Phenotype Manifest In
        Enhanced by
        Statement
        Reference

        hhAC2/hhts2 has germarium | temperature conditional phenotype, enhanceable by Scer\GAL4C587/hpoUAS.cWa

        (Li et al., 2015)
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        The rather moderate tumorous germarium phenotype characteristic for hhAC2/hhts2 (moved to the non-permissive temperature - 29[o]C - after eclosion) is strongly aggravated by expression of hpoScer\UAS.cWa under the control of Scer\GAL4C587 in the mutant background.

        (Li et al., 2015)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Comments
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        hhAC2
        (Li et al., 2015)
        Name Synonyms
        Secondary FlyBase IDs
          References (1)