FlyBase Allele Report: Dmel\Ythdc1[ΔN]

General Information

Symbol

Dmel\Ythdc1^ΔN

Species

D. melanogaster

Name

FlyBase ID

FBal0324798

Feature type

allele

Associated gene

Dmel\Ythdc1

Associated Insertion(s)

Carried in Construct

Also Known As

YT521-B^ΔN

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

Mutagen

CRISPR/Cas9

(Lence et al., 2016)

Progenitor genotype

Cytology

Description

A deletion of 602 bp (133-734 bp in the genome region chr3L:3370451..3374170 (reverse complemented)) that disrupts expression of both YT521-B isoforms.

(Lence et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:3,373,437..3,374,038 [-]

Comment:

A deletion of 602bp (reported as coordinates 133–734 relative to genome region 3L:3370451..3374170 , R6), which removes the N-terminal part of both Ythdc1 isoforms.

(Lence et al., 2016)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage

(Lence et al., 2016)

abnormal locomotor behavior | adult stage (with Df(3L)Exel6094)

(Lence et al., 2016)

short lived (with Df(3L)ED208)

(Kan et al., 2021)

viable

(Lence et al., 2016)

viable (with Df(3L)Exel6094)

(Lence et al., 2016)

viable (with Df(3R)BSC655)

(Lancaster et al., 2024)

visible

(Lence et al., 2016)

Phenotype Manifest In

wing

(Lence et al., 2016)

Detailed Description

Statement

Reference

YT521-B^ΔN/Df(3L)Exel6094 flies survive until adulthood but exhibit significantly decreased climbing ability and walking speed, as compared to controls.

YT521-B^ΔN/YT521-B^ΔN flies survive to adulthood, exhibit a significant wing posture defect and increased activity levels as compared to controls.

(Lence et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Ythdc1^ΔN/Ythdc1^ΔN is a suppressor | partially of increased mortality during development phenotype of Nab2^ex3

(Lancaster et al., 2024)

NOT Suppressor of

Statement

Reference

Ythdc1^ΔN/Ythdc1^ΔN is a non-suppressor of short lived phenotype of Nab2^ex3

(Lancaster et al., 2024)

Other

Statement

Reference

Nab2^ex3, Ythdc1^ΔN has partially lethal - majority die phenotype

(Lancaster et al., 2024)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

YT521-B^ΔN

(Lence et al., 2016)

Ythdc1^ΔN

(Kan et al., 2021, Worpenberg et al., 2021)

yt521-B^ΔN

(Lancaster et al., 2024)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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