FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\TrpA1-ACD-G4
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General Information
Symbol
Dmel\TrpA1-ACD-G4
Species
D. melanogaster
Name
FlyBase ID
FBal0324814
Feature type
allele
Associated gene
Dmel\TrpA1
Associated Insertion(s)
TI{GAL4}TrpA1-CD
Carried in Construct
Also Known As
trpA1-CDGAL4, TRPA1-CD-GAL4
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
CRISPR/Cas9
(Luo et al., 2017)
Progenitor genotype
TrpA1-CD-G4
(Luo et al., 2017)
Associated Insertion(s)
TI{GAL4}TrpA1-CD
Cytology
Description

A 2bp deletion in the exon that is common between the A and D isoforms has been introduced into the TrpA1-CD-G4 mutant background. This results in an allele that expresses only the B isoform of TrpA1. The GAL4 driver sequence and w+mW.hs marker that are inserted in the progenitor TrpA1-CD-G4 allele are still present in this allele.

(Luo et al., 2017)
Allele components
Component
Use(s)
Inserted element
TI{GAL4}
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      TrpA1-ACD-G4 mutant larvae have severely reduced rolling (escape) behavior in response to noxious temperature increases, compared to controls.

      (Luo et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (3)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      TrpA1-ACD-G4
      trpA1-ACDGAL4
      (Luo et al., 2017)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)