FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\wupAf06492
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General Information
Symbol
Dmel\wupAf06492
Species
D. melanogaster
Name
FlyBase ID
FBal0325176
Feature type
allele
Associated gene
Dmel\wupA
Associated Insertion(s)
PBac{WH}wupAf06492
Carried in Construct
Also Known As
UAS-TnIf06492
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Associated Insertion(s)
    PBac{WH}wupAf06492
    Cytology
    Description

    Insertion upstream of wupA, in the correct orientation such that a GAL4 driver can be used to drive over-expression of wupA from the Scer\UAS sites present in the inserted PBac{WH} element.

    (Casas-Tintó et al., 2016)
    Allele components
    Component
    Use(s)
    Inserted element
    PBac{WH}
    Regulatory region(s)
    UAS
    Also carries
    FRT
    Mutations Mapped to the Genome
    Curation Data
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 1 )
        Disease
        Evidence
        References
        model of  adenocarcinoma
        CEA
        (Casas-Tintó et al., 2016)
        CEA with NCA.UAS.cUa
        (Casas-Tintó et al., 2016)
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Somatic clones expressing wupAf06492 under the control of Scer\GAL4Act.PU in wandering third instar larval wing discs present a significant increase in cell number, but not in cell size, and a significant increase in the relative clonal area, as compared to control clones.

        (Casas-Tintó et al., 2016)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Enhanced by
        NOT Enhanced by
        Enhancer of
        Other
        Phenotype Manifest In
        Enhanced by
        NOT Enhanced by
        Enhancer of
        Other
        Additional Comments
        Genetic Interactions
        Statement
        Reference

        Somatic clones co-expressing wupAf06492 and l(2)glGD4047 under the control of Scer\GAL4Act.PU in wandering third instar larval wing discs present a significant increase in the relative clonal area, as compared to control clones; animals bearing clones co-expressing l(2)glGD4047 and wupAf06492 do not reach adulthood.

        Somatic clones co-expressing wupAf06492 and Nint.U.Scer\UAS under the control of Scer\GAL4Act.PU in wandering third instar larval wing discs present a significant increase in the relative clonal area, as compared to clones only expressing Nint.U.Scer\UAS but not to clones only expressing wupAf06492; animals bearing clones co-expressing wupAf06492 and Nint.U.Scer\UAS occasionally reach adulthood and present visible outgrowths.

        Somatic clones co-expressing wupAf06492 and Ras85DV12.cUa.Scer\UAS under the control of Scer\GAL4Act.PU in wandering third instar larval wing discs present a significant increase in the relative clonal area as compared to clones only expressing Ras85DV12.cUa.Scer\UAS, but not to clones only expressing wupAf06492, and lead to overgrowths protruding from the wing disc in almost half of cases.

        Somatic clones co-expressing l(2)glGD4047, Ras85DV12.cUa.Scer\UAS and wupAf06492 under the control of Scer\GAL4Act.PU in wandering third instar larvae wing discs exhibit a significant increase in relative clonal area as compared to clones only co-expressing l(2)glGD4047 and Ras85DV12.cUa.Scer\UAS or only expressing wupAf06492; animals bearing clones co-expressing l(2)glGD4047, Ras85DV12.cUa.Scer\UAS and wupAf06492 do not reach adulthood.

        (Casas-Tintó et al., 2016)
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescues

        Scer\GAL4Act.PU/wupAf06492 rescues wupAJF02172

        (Casas-Tintó et al., 2016)
        Comments

        The co-expression of wupAf06492 rescues the progressive decrease in the relative area of somatic clones expressing wupAJF02172 under the control of Scer\GAL4Act.PU in wandering third instar larval wing discs, even leading to a significant increase in the relative clonal area, as compared to control clones.

        (Casas-Tintó et al., 2016)
        Images (0)
        Mutant
        Wild-type
        Stocks (1)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (1)
        Reported As
        Symbol Synonym
        wupAf06492
        Name Synonyms
        Secondary FlyBase IDs
          References (2)