FB2026_02 , released June 18, 2026
Allele: Dmel\Fancm1-645.K84M
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General Information
Symbol
Dmel\Fancm1-645.K84M
Species
D. melanogaster
Name
FlyBase ID
FBal0325441
Feature type
allele
Associated gene
Dmel\Fancm
Associated Insertion(s)
Carried in Construct
P{Fancm.1-645.K84M}
Key Links
Transgenic product class
inframe_deletion
(Romero et al., 2016)
missense_variant
(Romero et al., 2016)
Mutagen
Nature of the Allele
Transgenic product class
inframe_deletion
(Romero et al., 2016)
missense_variant
(Romero et al., 2016)
Mutagen
in vitro construct
(Romero et al., 2016)
Progenitor genotype
Carried in construct
P{Fancm.1-645.K84M}
Cytology
Description

A truncated form of Fancm (amino acid residues 1-649) containing the K84M mutation is expressed under the control of its own promoter.

(Romero et al., 2016)
Allele components
Component
Use(s)
Regulatory region(s)
Fancm
Encoded product / tool
Fancm
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to rescue

      Fancm1-645.K84M fails to rescue Fancm0693/Fancmdel

      (Romero et al., 2016)
      Comments

      The increased number of mitotic crossovers as well as the low survival rate upon irradiation characteristic for Fancm0693/Fancmdel flies cannot be rescued by combination with Fancm1-645.K84M.

      (Romero et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Fancm1-645.K84M
      Fancm1-645K84M
      (Romero et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)