FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Fancmdel
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General Information
Symbol
Dmel\Fancmdel
Species
D. melanogaster
Name
FlyBase ID
FBal0325437
Feature type
allele
Associated gene
Dmel\Fancm
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

amorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - genetic evidence

(Romero et al., 2016)

amorphic allele - molecular evidence

(Romero et al., 2016)
Mutagen
CRISPR/Cas9
(Romero et al., 2016)
Progenitor genotype
Cytology
Description

Deletion that partially removes Fancm (extends from 3R:21480913..21487017 ). No transcript is produced.

(Romero et al., 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:21,480,913..21,487,017 [+]
(Romero et al., 2016)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fancm0693/Fancmdel transheterozygous flies display significant increase in the number of spontaneous mitotic crossovers (assayed in males) and are sensitive gamma irradiation (low survival rate).

      (Romero et al., 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Fancm0693/Fancmdel is rescued by Fancm+tFL

      (Romero et al., 2016)
      Partially rescued by

      Fancm0693/Fancmdel is partially rescued by FancmFLKM

      (Romero et al., 2016)

      Fancm0693/Fancmdel is partially rescued by Fancm1-645

      (Romero et al., 2016)
      Not rescued by

      Fancm0693/Fancmdel is not rescued by Fancm1-645.K84M

      (Romero et al., 2016)
      Comments

      The increased number of mitotic crossovers as well as the low survival rate upon irradiation characteristic for Fancm0693/Fancmdel flies is rescued to a varying degree by combination with Fancm+tFL or FancmFLKM or Fancm1-645 but cannot be rescued by combination with Fancm1-645.K84M.

      (Romero et al., 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Fancmdel
      (Romero et al., 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (1)