FlyBase Allele Report: Dmel\L2HGDH[12]

General Information

Symbol

Dmel\L2HGDH¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0325528

Feature type

allele

Associated gene

Dmel\L2HGDH

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

loss of function allele

Mutagen

CRISPR/Cas9

Nature of the Allele

Allele class

loss of function allele

(Li et al., 2017)

Mutagen

CRISPR/Cas9

(Li et al., 2017)

Progenitor genotype

Cytology

Description

29bp deletion in L2HGDH.

(Li et al., 2017)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

2L:18,973,271..18,973,299 [-]

Comment:

29bp deletion in L2HGDH.

(Li et al., 2017)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal stress response | adult stage (with L2HGDH¹⁴)

(Mahmoudzadeh et al., 2024)

increased mortality (with L2HGDH¹⁴)

(Mahmoudzadeh et al., 2024)

non-suppressor of variegation (with L2HGDH¹⁴)

(Li et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

L2HGDH¹²/L2HGDH¹⁴ transheterozygosity does not significantly suppress the variegated eye pigmentation phenotype in In(1)w^m4 adult flies.

(Li et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

L2HGDH¹²/L2HGDH¹⁴ is a suppressor of suppressor of variegation phenotype of In(1)w^m4, Ldh¹⁷/Ldh¹⁶

(Li et al., 2017)

Phenotype Manifest In

Other

Statement

Reference

Egfr^UAS.cBa, L2HGDH¹²/L2HGDH¹⁴, Scer\GAL4^c42 has adult lower segment of Malpighian tubule phenotype

(Mahmoudzadeh et al., 2024)

Additional Comments

Genetic Interactions

Statement

Reference

The suppression of the variegated eye pigmentation phenotype characteristic for In(1)w^m4 adult flies by ImpL3¹⁶/ImpL3¹⁷ transheterozygosity is blocked by combination with L2HGDH¹²/L2HGDH¹⁴ (all in the In(1)w^m4 background): the ImpL3¹⁶/ImpL3¹⁷;L2HGDH¹²/L2HGDH¹⁴ double transheterozygotes display similar level of position effect variegation as In(1)w^m4-only controls.