FlyBase Allele Report: Dmel\Ldh[17]

General Information

Symbol

Dmel\Ldh¹⁷

Species

D. melanogaster

Name

FlyBase ID

FBal0325525

Feature type

allele

Associated gene

Dmel\Ldh

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Li et al., 2017)

Mutagen

P-element activity

(Li et al., 2017)

Progenitor genotype

P{EPgy2}EY07426

(Li et al., 2017)

Cytology

Description

1542bp deletion (revision of data reported in FBrf0234785).

(Tennessen, 2017.8.21)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:6,262,345..6,263,886 [-]

Comment:

1542 bp deletion resulting from the imprecise excision of P{EPgy2}EY07426.

(Tennessen, 2017.8.21)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

partially lethal (with Ldh¹⁶)

(Li et al., 2019)

some die during third instar larval stage (with Ldh¹⁶)

(Li et al., 2019, Li et al., 2017)

suppressor of variegation (with Ldh¹⁶), with In(1)w^m4

(Li et al., 2017)

Phenotype Manifest In

Detailed Description

Statement

Reference

Ldh¹⁶/Ldh¹⁷ larvae do not show major developmental defects.

(Li et al., 2019)

ImpL3¹⁶/ImpL3¹⁷ transheterozygosity significantly suppresses the variegated eye pigmentation phenotype in In(1)w^m4 adult flies.

(Li et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ldh¹⁷/Ldh¹⁶ has increased mortality during development phenotype, enhanceable by Gpdh1^A10/Gpdh1^B18

(Li et al., 2019)

Suppressed by

Statement

Reference

In(1)w^m4, Ldh¹⁷/Ldh¹⁶ has suppressor of variegation phenotype, suppressible by L2HGDH¹²/L2HGDH¹⁴

(Li et al., 2017)

Suppressor of

Statement

Reference

Ldh¹⁷ is a suppressor | partially of abnormal wound healing | larval stage phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Other

Statement

Reference

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has abnormal developmental rate | second instar larval stage phenotype

(Li et al., 2019)

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has decreased body size | second instar larval stage phenotype

(Li et al., 2019)

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has abnormal size | second instar larval stage phenotype

(Li et al., 2019)

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has some die during first instar larval stage phenotype

(Li et al., 2019)

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has lethal - all die before end of second instar larval stage phenotype

(Li et al., 2019)

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has majority die during second instar larval stage phenotype

(Li et al., 2019)

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has visible | second instar larval stage phenotype

(Li et al., 2019)

Phenotype Manifest In

Suppressor of

Statement

Reference

Ldh¹⁷ is a suppressor | partially of larval multidendritic class IV neuron phenotype of Pi3K92E^{UAS.Tag:MYC,Tag:PM(hKRAS)}, Scer\GAL4^repo, btl::Egfr^λ.UAS

(Li et al., 2020)

Other

Statement

Reference

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has larval brain | second instar larval stage phenotype

(Li et al., 2019)

Gpdh1^A10/Gpdh1^B18, Ldh¹⁷/Ldh¹⁶ has embryonic/larval posterior midgut | second instar larval stage phenotype

(Li et al., 2019)

Additional Comments

Genetic Interactions

Statement

Reference

Ldh¹⁶/Ldh¹⁷, Gpdh1^A10/Gpdh1^B18 larvae show severe developmental defects: second instar larvae are much smaller and have a much lower body weight, as compared to either single transheterozygous condition and wild-type controls; 92-96h after egg-laying, larvae are still at L2, whereas either single transheterozygous condition and wild-type controls are already at L3; at L2 brains are much smaller and, even in size-matched larvae, presents significantly lower mitotic index, as compared to either single transheterozygous condition and wild-type controls; L2 posterior midguts are also much smaller than either single transheterozygous condition and wild-type controls.

(Li et al., 2019)

The suppression of the variegated eye pigmentation phenotype characteristic for In(1)w^m4 adult flies by ImpL3¹⁶/ImpL3¹⁷ transheterozygosity is blocked by combination with L2HGDH¹²/L2HGDH¹⁴ (all in the In(1)w^m4 background): the ImpL3¹⁶/ImpL3¹⁷;L2HGDH¹²/L2HGDH¹⁴ double transheterozygotes display similar level of position effect variegation as In(1)w^m4-only controls.

(Li et al., 2017)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

94699

w¹¹¹⁸; Ldh¹⁷/TM3, P{Dfd-GMR-nvYFP}3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

ImpL3¹⁷

Ldh¹⁷

(Li et al., 2020, Li et al., 2019, Tennessen, 2017.8.21)

dLdh¹⁷

(Li et al., 2017)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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