FB2026_02 , released June 18, 2026
Allele: Dmel\Dlishc
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General Information
Symbol
Dmel\Dlishc
Species
D. melanogaster
Name
FlyBase ID
FBal0327324
Feature type
allele
Associated gene
Dmel\Dlish
Associated Insertion(s)
TI{TI}Dlishc
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Misra and Irvine, 2016)
Mutagen
CRISPR/Cas9
(Misra and Irvine, 2016)
gene targeting by homologous recombination
(Misra and Irvine, 2016)
Progenitor genotype
Associated Insertion(s)
TI{TI}Dlishc
Cytology
Description

Replacement of the endogenous Dlish locus with a Disc\RFPDsRed.3xP3.cUa marker.

(Misra and Irvine, 2016)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
delins
2R:17,723,388..17,724,949 [+]
Comment:

The coding region of Dlish has been replaced with a Disc\RFPDsRed.3xP3.cUa marker.

(Misra and Irvine, 2018.3.9)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Dlishc homozygotes and Dlishc/Df(2R)BSC347 transheterozygotes exhibit significant decreases in total wing area, wing inter-crossvein distance and tarsal length, which is associated with the occasional presence of only four tarsal segments, as compared to controls. Under both these allelic combinations, some hair orientation defects are observed at the proximal anterior wing region and, less severely, at the posterior dorsal abdomen, as compared to controls.

      (Misra and Irvine, 2016)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhanced by
      Statement
      Reference

      Dlishc has abnormal size phenotype, non-enhanceable by ftG-rv/ftG-rv

      (Misra and Irvine, 2016)
      Suppressor of
      Statement
      Reference

      Dlishc/Dlishc is a suppressor of lethal phenotype of ftG-rv

      (Misra and Irvine, 2016)
      Phenotype Manifest In
      NOT Enhanced by
      Statement
      Reference

      Dlishc has wing phenotype, non-enhanceable by ftG-rv/ftG-rv

      (Misra and Irvine, 2016)

      Dlishc has abdominal tergite marginal bristle phenotype, non-enhanceable by ftG-rv/ftG-rv

      (Misra and Irvine, 2016)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Homozygosity for Dlishc suppresses the lethality of ftG-rv homozygotes, although adults are recovered at only about one third of the expected frequency.

      The small wing area phenotype and mild abdomen hair orientation defects observed in Dlishc single homozygotes are not exacerbated by additional ftG-rv homozygosity.

      (Misra and Irvine, 2016)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      Dlishc is rescued by DlishEGFP

      (Misra and Irvine, 2016)
      Comments

      DlishT:Avic\GFP-EGFP rescues all the phenotypes observed in Dlishc homozygotes - i.e. the decreases in wing area, in inter-crossvein distance and in tarsal length, and the mild hair orientation defects in the proximal anterior wing.

      (Misra and Irvine, 2016)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Dlishc
      Vamc
      (Misra and Irvine, 2018.3.9, Misra and Irvine, 2016)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)