FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Ythdc1NP3
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General Information
Symbol
Dmel\Ythdc1NP3
Species
D. melanogaster
Name
FlyBase ID
FBal0327403
Feature type
allele
Associated gene
Dmel\Ythdc1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

loss of function allele

Mutagen
Nature of the Allele
Allele class

loss of function allele

(Kan et al., 2017)
Mutagen
CRISPR/Cas9
(Kan et al., 2017)
Progenitor genotype
Cytology
Description

An indel early in the coding region of the both the PA and PB isoforms, causing a frameshift in the PA coding region and deletion of the initiating ATG in the PB coding region, and therefore expected to produce a non-functional protein.

(Kan et al., 2017)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:3,373,838..3,373,845 [-]
Comment:

An 8 bp deletion after the ATG of Ythdc1-PB (ATG1) which removes the second in frame ATG (ATG2) that maps three amino acids downstream of ATG1. This leads to a frameshift after ATG1 and early translation termination. Ythdc1-PA is disrupted.

(Kan et al., 2017)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Ythdc1NP3 homozygotes and Ythdc1NP3/Df(3L)ED208 transheterozygotes exhibit a flightless phenotype, which is associated with a partially penetrant "held-out" wing phenotype in the transheterozygotes. Ythdc1NP3/Df(3L)ED208 transheterozygous adults exhibit additional locomotion defects, as shown by their significantly decreased climbing capacity (more pronounced in males than in females) in negative geotaxis assays, as compared to controls; the transheterozygous females exhibit mild oogenesis defects, as shown by the small decrease in the number of egg chambers and by the frequent 'empty' ovarioles, despite the apparently normal development of egg chambers, as compared to controls.

      (Kan et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      Ythdc1NP3/Ythdc1[+] is an enhancer of abnormal sex-determination phenotype of Sxl[+]/SxlfP7B0, da3

      (Kan et al., 2017)
      Other
      Phenotype Manifest In
      Other
      Statement
      Reference

      Sxl[+]/SxlfP7B0, Ythdc1NP3 has spectrosome | oogenesis phenotype

      (Kan et al., 2017)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      YT521-BNP3
      (Kan et al., 2017)
      Ythdc1NP3
      Name Synonyms
      Secondary FlyBase IDs
        References (1)